Grapefruit

font size

Are there any interactions with medications?



Amiodarone (Cordarone)
Interaction Rating: Major Do not take this combination.

Grapefruit juice can increase how much amiodarone (Cordarone) the body absorbs. Drinking grapefruit juice while taking amiodarone (Cordarone) might increase the effects and side effects. Avoid drinking grapefruit juice if you are taking amiodarone (Cordarone).



Artemether (Artenam, Paluther)
Interaction Rating: Major Do not take this combination.

The body breaks down artemether (Artenam, Paluther) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down artemether (Artenam, Paluther). Drinking grapefruit juice while taking artemether (Artenam, Paluther) might increase the effects and side effects of artemether (Artenam, Paluther). Do not drink grapefruit juice if you are taking artemether (Artenam, Paluther).



Atorvastatin (Lipitor)
Interaction Rating: Major Do not take this combination.

The body breaks down some medications used for lowering cholesterol ("statins") to get rid of them. Grapefruit juice might decrease how quickly the body breaks down some medications used for lowering cholesterol. Drinking grapefruit juice while taking these medications might increase the effects and side effects of these medications.

Grapefruit might interact with some of these medications including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor), but grapefruit juice does not interact with some other medications used for lowering cholesterol including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).



Buspirone (BuSpar)
Interaction Rating: Major Do not take this combination.

Grapefruit juice might increase how much buspirone (BuSpar) the body absorbs. Drinking grapefruit juice while taking buspirone (BuSpar) might increase the effects and side effects of buspirone (BuSpar).



Carbamazepine (Tegretol)
Interaction Rating: Major Do not take this combination.

Grapefruit juice might increase how much carbamazepine (Tegretol) the body absorbs. Drinking grapefruit juice while taking carbamazepine (Tegretol) might increase the effects and side effects of carbamazepine (Tegretol).



Carvedilol (Coreg)
Interaction Rating: Major Do not take this combination.

The body breaks down carvedilol (Coreg) to get rid of it. Grapefruit juice seems to decrease how quickly the body breaks down carvedilol (Coreg). Drinking grapefruit juice while taking carvedilol (Coreg) might increase the effects and side effects of carvedilol (Coreg).



Cisapride (Propulsid)
Interaction Rating: Major Do not take this combination.

Grapefruit juice might decrease how quickly the body gets rid of cisapride (Propulsid). Drinking grapefruit juice while taking cisapride (Propulsid) might increase the effects and side effects of cisapride (Propulsid).



Clomipramine (Anafranil)
Interaction Rating: Major Do not take this combination.

The body breaks down clomipramine (Anafranil) to get rid of it. Grapefruit juice might decrease how quickly the body gets rid of clomipramine (Anafranil). Taking grapefruit juice along with clomipramine (Anafranil) might increase the effects and side effects of clomipramine (Anafranil).



Cyclosporine (Neoral, Sandimmune)
Interaction Rating: Major Do not take this combination.

Grapefruit might increase how much cyclosporine (Neoral, Sandimmune) the body absorbs. Drinking grapefruit juice while taking cyclosporine (Neoral, Sandimmune) might increase the side effects of cyclosporine.



Dextromethorphan (Robitussin DM, and others)
Interaction Rating: Major Do not take this combination.

The body breaks down dextromethorphan (Robitussin DM, others) to get rid of it. Grapefruit might decrease how quickly the body breaks down dextromethorphan (Robitussin DM, others). Drinking grapefruit juice while taking dextromethorphan (Robitussin DM, others) might increase the effects and side effects of dextromethorphan (Robitussin DM, others).



Estrogens
Interaction Rating: Major Do not take this combination.

The body breaks down estrogens to get rid of them. Grapefruit juice seems to decrease how quickly the body breaks down estrogens and increase how much estrogen the body absorbs. Drinking grapefruit juice while taking estrogens might increase estrogen levels and side effects associated with estrogen such as breast cancer.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol (Climara, Vivelle, Estring), and others.



Etoposide (VePesid)
Interaction Rating: Major Do not take this combination.

Grapefruit might decrease how much etoposide (VePesid) the body absorbs. Drinking grapefruit juice while taking etoposide (VePesid) might decrease the effectiveness of etoposide (VePesid). To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.



Lovastatin (Mevacor)
Interaction Rating: Major Do not take this combination.

The body breaks down some medications used for lowering cholesterol ("statins") to get rid of them. Grapefruit juice might decrease how quickly the body breaks down some medications used for lowering cholesterol. Drinking grapefruit juice while taking these medications might increase the effects and side effects of these medications.

Grapefruit might interact with some of these medications including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor), But grapefruit juice does not interact with some other medications used for lowering cholesterol including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Major Do not take this combination.

Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Drinking grapefruit juice while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.



Medications for high blood pressure (Calcium channel blockers)
Interaction Rating: Major Do not take this combination.

Grapefruit juice might increase how much medication for high blood pressure the body absorbs. Drinking grapefruit juice while taking some medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.



Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates)
Interaction Rating: Major Do not take this combination.

Some medications are moved by pumps in cells. Grapefruit might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. To avoid this interaction, separate taking these medications from consuming grapefruit by at least 4 hours.

Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).



Methylprednisolone
Interaction Rating: Major Do not take this combination.

The body breaks down methylprednisolone to get rid of it. Grapefruit juice can decrease how quickly the body gets rid of methylprednisolone. Drinking grapefruit juice while taking methylprednisolone might increase the effects and side effects of methylprednisolone.



Praziquantel (Biltricide)
Interaction Rating: Major Do not take this combination.

The body breaks down praziquantel (Biltricide) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down praziquantel (Biltricide). Drinking grapefruit juice while taking praziquantel (Biltricide) might increase the effects and side effects of praziquantel (Biltricide).



Quinidine
Interaction Rating: Major Do not take this combination.

The body breaks down quinidine to get rid of it. Grapefruit juice might decrease how fast the body gets rid of quinidine. Drinking grapefruit juice while taking quinidine might increase the chance of side effects.



Scopolamine (Transderm Scop)
Interaction Rating: Major Do not take this combination.

The body breaks down scopolamine to get rid of it. Grapefruit juice can decrease how fast the body breaks down scopolamine. Drinking grapefruit juice while taking scopolamine might increase the effects and side effects of scopolamine.



Sedative medications (Benzodiazepines)
Interaction Rating: Major Do not take this combination.

Sedative medications can cause sleepiness and drowsiness. Grapefruit juice can decrease how quickly the body breaks down some medications. Drinking grapefruit juice while taking some sedative medications can increase the effects and side effects of some sedative medications.

Some sedative medications (benzodiazepines) that might interact with grapefruit juice include diazepam (Valium), midazolam (Versed), quazepam (Doral), and triazolam (Halcion).



Sildenafil (Viagra)
Interaction Rating: Major Do not take this combination.

The body breaks down sildenafil (Viagra) to get rid of it. Grapefruit can decrease how quickly the body breaks down sildenafil (Viagra). Drinking grapefruit juice while taking sildenafil (Viagra) can increase the effects and side effects of sildenafil.



Simvastatin (Zocor)
Interaction Rating: Major Do not take this combination.

The body breaks down some medications used for lowering cholesterol ("statins") to get rid of them. Grapefruit juice might decrease how quickly the body breaks down some medications used for lowering cholesterol. Drinking grapefruit juice while taking these medications might increase the effects and side effects of these medications.

Grapefruit might interact with some of these medications including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor), But grapefruit juice does not interact with some other medications used for lowering cholesterol including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).



Terfenadine (Seldane)
Interaction Rating: Major Do not take this combination.

Grapefruit can increase how much terfenadine (Seldane) that the body absorbs. Drinking grapefruit juice while taking terfenadine (Seldane) might increase the effects and side effects of terfenadine (Seldane).



Aliskiren (Tekturna, Rasilez)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Aliskiren (Tekturna, Rasilez) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much aliskiren (Tekturna, Rasilez) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.



Caffeine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Grapefruit might decease how quickly the body gets rid of caffeine. Drinking grapefruit while taking caffeine might increase the side effects of caffeine including jitteriness, headache, and a fast heartbeat.



Erythromycin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down erythromycin to get rid of it. Grapefruit can decrease how quickly the body gets rid of erythromycin. Taking grapefruit juice along with erythromycin might increase the effects and side effects of erythromycin.



Fexofenadine (Allegra)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Grapefruit might decrease how much fexofenadine (Allegra) the body absorbs. Drinking grapefruit juice while taking fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra). To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.



Fluvoxamine (Luvox)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Grapefruit juice can increase how much fluvoxamine (Luvox) the body absorbs. Drinking grapefruit juice while taking fluvoxamine (Luvox) might increase the effects and side effects of fluvoxamine (Luvox).



Itraconazole (Sporanox)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Itraconazole (Sporanox) is used to treat fungal infections. Grapefruit juice might affect how much itraconazole (Sporanox) the body absorbs. But there is not enough reliable information to know if this is an interaction to be concerned about.



Levothyroxine (Synthroid, others)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Levothyroxine (Synthroid, others) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much levothyroxine (Synthroid, others) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.



Losartan (Cozaar)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The liver activates losartan (Cozaar) to make it work. Grapefruit juice might decrease how quickly the body activates losartan (Cozaar). Drinking grapefruit juice while taking losartan (Cozaar) might decrease the effectiveness of losartan.



Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.



Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.



Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.



Methadone (Dolophine)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Grapefruit juice might increase how much methadone (Dolophine) the body absorbs. Drinking grapefruit juice while taking methadone (Dolophine) might increase the effects and side effects of methadone (Dolophine).



Nilotinib (Tasigna)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Grapefruit juice can increase how much Nilotinib (Tasigna) the body absorbs. Drinking grapefruit juice while taking Nilotinib (Tasigna) might increase the effects and side effects. Avoid drinking grapefruit juice if you are taking Nilotinib (Tasigna).



Saquinavir (Fortovase, Invirase)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Drinking grapefruit juice can increase how much saquinavir (Fortovase, Invirase) the body absorbs. Drinking grapefruit juice while taking saquinavir (Fortovase, Invirase) might increase the effects and side effects of saquinavir.



Theophylline
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Drinking grapefruit juice might decrease the effects of theophylline. There's not enough information to know if this is a big concern.



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. Drinking grapefruit juice might increase the effects of warfarin (Coumadin) and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.



Acebutolol (Sectral)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Acebutolol (Sectral) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much acebutolol (Sectral) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.



Amprenavir (Agenerase)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Grapefruit might slightly decrease how much amprenavir (Agenerase) is absorbed by the body. However, this probably is not an important interaction to be concerned about.

Dosing considerations for Grapefruit.

The appropriate dose of grapefruit depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for grapefruit. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations

From WebMD