May 25, 2017
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Guaifenex PSE 60

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Guaifenex PSE 60

Guaifenex® PSE 60
(guaifenesin/pseudoephedrine) Extended-release Tablets Expectorant/Nasal Decongestant


Each bisected, blue Guaifenex® PSE 60 (guaifenesin pseudoephedrine extended-release tablets) capsule shaped extended-release tablet provides 60 mg pseudoephedrine hydrochloride and 600 mg guaifenesin in an extended-release formulation intended for oral administration. Inactive ingredients: calcium phosphate dibasic, hydroxypropyl methylcellulose, lactose, lake blue No. 1 FD&C, magnesium stearate, povidone, silicon dioxide colloidal, and stearic acid.

Guaifenesin is an expectorant. Chemically, it is 3-(2-methoxyphe-noxy)-1, 2-propanediol and has the following structural formula:

Guaifenesin  Structural Formula Illustration

Pseudoephedrine hydrochloride is a nasal decongestant. Chemically, it is [S-(R*,R*)]-α-[1-(methylamino)ethyl] benzen-emethanol hydrochloride and has the following structural formula:

Pseudoephedrine hydrochloride   Structural Formula Illustration

What are the possible side effects of guaifenesin and pseudoephedrine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using guaifenesin and pseudoephedrine and call your doctor at once if you have:

  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness,...

Read All Potential Side Effects and See Pictures of Guaifenex PSE 60 »

Last reviewed on RxList: 8/5/2008
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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