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Guaifenex PSE 60

Last reviewed on RxList: 6/9/2017
Guaifenex PSE 60 Patient Information Including Side Effects

Brand Names: Altarussin PE, Ambifed-G, Biotuss PE, Despec-SR, D-Feda II, ExeFen-IR, Guiatex II SR, Levall G, Maxifed, Maxifed-G, Mucinex D, Mucinex D Max Strength, Nasabid SR, Poly-Vent IR, Q-Tussin PE, Respaire-30, Robitussin PE, Robitussin Severe Congestion, Sinutab Non Drying, SudaTex-G, Triaminic Softchews Chest Congestion, We Mist II LA, We Mist LA

Generic Name: guaifenesin and pseudoephedrine (Pronunciation: gwye FEN e sin, SOO doe ee FED rin)

What is guaifenesin and pseudoephedrine (Guaifenex PSE 60)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Guaifenesin and pseudoephedrine is a combination medicine used to treat stuffy nose, sinus congestion, and cough caused by allergies or the common cold.

Guaifenesin and pseudoephedrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of guaifenesin and pseudoephedrine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using guaifenesin and pseudoephedrine and call your doctor at once if you have:

  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Other common side effects may include:

  • mild dizziness or headache;
  • feeling restless or excited;
  • sleep problems (insomnia);
  • mild nausea, vomiting, or stomach upset;
  • mild loss of appetite;
  • warmth, redness, or tingly feeling under your skin; or
  • skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Guaifenex PSE 60 (guaifenesin pseudoephedrine extended-release tablets) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about guaifenesin and pseudoephedrine?

Do not give this medication to a child younger than 4 years old. Always\s ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not use a cough or cold medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Guaifenesin and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains guaifenesin or pseudoephedrine.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Guaifenex PSE 60 Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking guaifenesin and pseudoephedrine?

You should not use this medication if you are allergic to guaifenesin or pseudoephedrine, or to other decongestants, diet pills, stimulants, or ADHD medications.

Do not use a cough or cold medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

  • heart disease or high blood pressure;
  • diabetes; or
  • a thyroid disorder.

It is not known whether guaifenesin and pseudoephedrine will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Guaifenesin and pseudoephedrine may pass into breast milk and may harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

How should I take guaifenesin and pseudoephedrine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or cough medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

Take with food if this medicine upsets your stomach.

Do not take guaifenesin and pseudoephedrine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery, tell the surgeon ahead of time if you have taken a cough or cold medicine within the past few days.

Store at room temperature away from moisture, heat, and light.

Guaifenex PSE 60 Patient Information including If I Miss a Dose

What happens if I miss a dose?

Since cold medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking guaifenesin and pseudoephedrine?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of guaifenesin and pseudoephedrine.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any other cold, cough, or allergy medicine. Guaifenesin and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains guaifenesin or pseudoephedrine.

What other drugs will affect guaifenesin and pseudoephedrine?

Ask a doctor or pharmacist if it is safe for you to use guaifenesin and pseudoephedrine if you are also using any of the following drugs:

  • methyldopa;
  • blood pressure medications;
  • a beta-blocker such as atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol, and others; or
  • an antidepressant such as amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, and others.

This list is not complete. Other drugs may interact with guaifenesin and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about guaifenesin and pseudoephedrine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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