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Medical Editor: John P. Cunha, DO, FACOEP
Guanfacine hydrochloride (Brand Name: Tenex) is used to treat high blood pressure (hyptertension). It is a centrally acting antihypertensive with a2-adrenoceptor agonist properties. This medication is available in generic form. Common side effects include dry mouth, sedation, weakness, dizziness, constipation, and impotence.
The recommended initial dose of guanfacine hydrochloride when given alone or in combination with another antihypertensive drug is 1 mg daily at bedtime to minimize drowsiness. A doctor may increase dosage until the desired result is obtained. Guanfacine hydrochloride may interact with valproic acid, drugs affecting liver enzymes that remove guanfacine from your body (e.g., azole antifungals, rifamycins), products that cause drowsiness, including alcohol, antihistamines, drugs for sleep or anxiety, muscle relaxants, narcotics, cough-and-cold products, diet aids, or non-steroidal anti-inflammatory drugs (NSAIDs). Guanfacine hydrochloride should be used during pregnancy only if prescribed. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding. Stopping guanfacine hydrochloride suddenly could cause severe high blood pressure, anxiety, and other side effects.
Our Guanfacine hydrochloride Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Guanfacine hydrochloride (guanfacine) tablets are indicated in the management of hypertension. Guanfacine may be given alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.
Read the complete drug monograph for Guanfacine Hydrochloride »
Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.