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Guanfacine Hydrochloride

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Guanfacine Hydrochloride

INDICATIONS

Guanfacine hydrochloride (guanfacine) tablets are indicated in the management of hypertension. Guanfacine may be given alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.

DOSAGE AND ADMINISTRATION

The recommended initial dose of guanfacine (as the hydrochloride) when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. If after 3 to 4 weeks of therapy, 1 mg does not give a satisfactory result, a dose of 2 mg may be given, although most of the effect of guanfacine is seen at 1 mg (see CLINICAL PHARMACOLOGY). Higher daily doses have been used, but adverse reactions increase significantly with doses above 3 mg/day.

The frequency of rebound hypertension is low, but it can occur. When rebound occurs, it does so after 2-4 days, which is delayed compared with clonidine hydrochloride. This is consistent with the longer half-life of guanfacine. In most cases, after abrupt withdrawal of guanfacine, blood pressure returns to pretreatment levels slowly (within 2-4 days) without ill effects.

HOW SUPPLIED

Guanfacine hydrochloride is available in 2 tablet strengths of guanfacine (as the hydrochloride) as follows:

Guanfacine Hydrochloride (guanfacine) Tablets 1 mg, are pink, round tablets, debossed with WATSON 444 and are available in bottles of 100.

Guanfacine Hydrochloride (guanfacine) Tablets 2 mg, are peach, round tablets, debossed with WATSON 453 and are available in bottles of 100.

Bottles of 100 tablets are supplied with child-resistant closures.

Store at controlled room temperature 15°-30°C (59°-86°F).

Dispense in a tight, light-resistant container.

Watson Laboratories, Inc. Corona, CA 92880 USA. Revised: April 2003. FDA rev date: 3/12/2002

Last reviewed on RxList: 12/6/2007
This monograph has been modified to include the generic and brand name in many instances.

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