"Nov. 1, 2012 -- Having even mildly elevated blood pressure at midlife prematurely ages the brain, a new study shows.
Researchers say the early changes seen with higher blood pressure may set the stage for problems with thinking, memor"...
Guanfacine hydrochloride (guanfacine) tablets are indicated in the management of hypertension. Guanfacine may be given alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.
DOSAGE AND ADMINISTRATION
The recommended initial dose of guanfacine (as the hydrochloride) when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. If after 3 to 4 weeks of therapy, 1 mg does not give a satisfactory result, a dose of 2 mg may be given, although most of the effect of guanfacine is seen at 1 mg (see CLINICAL PHARMACOLOGY). Higher daily doses have been used, but adverse reactions increase significantly with doses above 3 mg/day.
The frequency of rebound hypertension is low, but it can occur. When rebound occurs, it does so after 2-4 days, which is delayed compared with clonidine hydrochloride. This is consistent with the longer half-life of guanfacine. In most cases, after abrupt withdrawal of guanfacine, blood pressure returns to pretreatment levels slowly (within 2-4 days) without ill effects.
Guanfacine hydrochloride is available in 2 tablet strengths of guanfacine (as the hydrochloride) as follows:
Guanfacine Hydrochloride (guanfacine) Tablets 1 mg, are pink, round tablets, debossed with WATSON 444 and are available in bottles of 100.
Guanfacine Hydrochloride (guanfacine) Tablets 2 mg, are peach, round tablets, debossed with WATSON 453 and are available in bottles of 100.
Bottles of 100 tablets are supplied with child-resistant closures.
Store at controlled room temperature 15°-30°C (59°-86°F).
Dispense in a tight, light-resistant container.
Watson Laboratories, Inc. Corona, CA 92880 USA. Revised: April 2003. FDA rev
Last reviewed on RxList: 12/6/2007
Additional Guanfacine Hydrochloride Information
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