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Gyne-Lotrimin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/28/2016

Gyne-Lotrimin (clotrimazole vaginal cream) is an antifungal medication used to treat vaginal candida (yeast) infections. Gyne-Lotrimin is available over-the-counter and in generic versions. Common side effects of Gyne-Lotrimin include:

  • vaginal or urethral burning/itching/pain/irritation,
  • an increased need to urinate, or
  • lower abdominal cramps.

Seek immediate medical attention if you have rare but serious symptoms of a serious allergic reaction to Gyne-Lotrimin including:

  • rash,
  • itching/swelling (especially of the face/tongue/throat),
  • severe dizziness, or
  • trouble breathing.

Fill the applicator with the cream and then insert one applicatorful dose of Gyne-Lotrimin cream into the vagina every day, preferably at bedtime. Dispose of applicator after use. Repeat this procedure with a new applicator for 7 consecutive days. In order to kill the yeast completely, you must use Gyne-Lotrimin the full seven days, even if symptoms are relieved sooner. Gyne-Lotrimin may interact with other vaginal creams or douches used at the same time. Tell your doctor all medications and supplements you use. Do not use Gyne-Lotrimin for self-treatment if you are pregnant. During pregnancy, Gyne-Lotrimin should be used only when recommended by your doctor. If you are pregnant, follow your doctor's instructions on how to use the applicator to insert this medication. It is unknown whether this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Gyne-Lotrimin (clotrimazole vaginal cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Gyne-Lotrimin in Detail - Patient Information: Side Effects

Stop using clotrimazole vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Gyne-Lotrimin (Clotrimazole Vaginal Cream)

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Gyne-Lotrimin Overview - Patient Information: Side Effects

SIDE EFFECTS: See also Uses section.

Vaginal/urethral burning/itching/pain, or lower abdominal cramps may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Gyne-Lotrimin (Clotrimazole Vaginal Cream)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Gyne-Lotrimin FDA Prescribing Information: Side Effects
(Adverse Reactions)


No information provided.

Read the entire FDA prescribing information for Gyne-Lotrimin (Clotrimazole Vaginal Cream)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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