Halaven (Eribulin Mesylate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Halaven

Breast Cancer During Pregnancy »

Introduction

Breast cancer is the most common cancer in pregnant women and tends to affect women in their mid-30s. Although only about 1 in every 1,000 pregnant women get breast cancer, the disease can be devastating to both the mother and her child -- so it is essential that pregnant women and their doctors continue to do routine breast exams and thoroughly investigate any suspicious lumps.

A major problem is that a lot of changes take place in a woman's breasts during pregnancy. This makes it harder to identify suspicious lumps. In addition, breast cancer tumors in pregnant women are often larger and more advanced by the time they are detected than lumps in women of the same age who are not pregnant.

How is breast cancer diagnosed in pregnant women?

The best thing you can do while pregnant is to see your obstetrician regularly. These doctor visits, called prenatal (or "before birth") visits, are very important in keeping both you and y...

Read the Breast Cancer During Pregnancy article »

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Halaven

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HALAVEN®
(eribulin mesylate)

DRUG DESCRIPTION

HALAVEN (eribulin mesylate) Injection is a non-taxane microtubule dynamics inhibitor. Eribulin mesylate is a synthetic analogue of halichondrin B, a product isolated from the marine sponge Halichondria okadai. The chemical name for eribulin mesylate is 11,15:18,21:24,28Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-, methanesulfonate (salt). It has a molecular weight of 826.0 (729.9 for free base). The empirical formula is C₄₀H₅₉NO₁₁•CH₄O₃S. Eribulin mesylate has the following structural formula:

HALAVEN® (eribulin mesylate) Structural Formula Illustration

HALAVEN is a clear, colorless, sterile solution for intravenous administration. Each vial contains 1 mg of eribulin mesylate as a 0.5 mg/mL solution in ethanol: water (5:95).

What are the precautions when taking eribulin mesylate (Halaven)?

Before using halcinonide, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems.

Do not use if there is an infection or sore present in the area to be treated.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you...

Read All Potential Precautions of Halaven »

Last reviewed on RxList: 3/2/2012
This monograph has been modified to include the generic and brand name in many instances.