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Doxercalciferol, the active ingredient in Hectorol® (doxercalciferol liquid filled capsule) , is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form lα,25-dihydroxyvitamin D2 (lα,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Hectorol (doxercalciferol liquid filled capsule) is available as soft gelatin capsules containing 0.5 mcg, 1 mcg or 2.5 mcg doxercalciferol. Each capsule also contains fractionated triglyceride of coconut oil, ethanol, and butylated hydroxyanisole (BHA). The capsule shells contain gelatin, glycerin and titanium dioxide. In addition, the 0.5 mcg capsule shells contain yellow iron oxide and FD&C Red No. 40, the 1 mcg capsule shells contain FD&C Yellow No. 6, and the 2.5 mcg capsule shells contain yellow iron oxide.
Doxercalciferol is a colorless crystalline compound with a calculated molecular weight of 412.66 and a molecular formula of C28H44O2. It is soluble in oils and organic solvents, but is relatively insoluble in water. Chemically, doxercalciferol is (lα,3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraene-l,3-diol. The structural formula is presented in Figure 1 below:
Figure 1: Chemical Structure of Doxercalciferol
Other names frequently used for doxercalciferol are la-hydroxyvitamin D2, lα-OH-D2, and la-hydroxyergocalciferol.
What are the possible side effects of doxercalciferol (Hectorol)?
If you experience any of the following serious side effects, stop taking doxercalciferol and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- an irregular heartbeat;
- increased nighttime urination; or
- abdominal pain.
Contact your doctor if you experience any of the following side effects:
- nausea, vomiting, or decreased appetite;
What are the precautions when taking doxercalciferol liquid filled capsule (Hectorol)?
Before taking doxercalciferol, tell your doctor or pharmacist if you are allergic to it; or to vitamin D products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., irregular heartbeat), liver disease, high calcium blood levels (hypercalcemia), high phosphate blood levels (hyperphosphatemia), seizure.
Tell your doctor if you are pregnant before using this medication.
It is not known whether this medication passes into breast milk. Consult your doctor before...
Last reviewed on RxList: 4/12/2011
This monograph has been modified to include the generic and brand name in many instances.
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