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Hectorol Injection

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Hectorol Injection

HECTOROL
(doxercalciferol) Injection 4 mcg/2mL (2 mcg/mL)

Hectorol Injection

DRUG DESCRIPTION

Doxercalciferol, the active ingredient in Hectorol (doxercalciferol injection) , is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(0H)2D2), a naturally occurring, biologically active form of vitamin D2. Hectorol (doxercalciferol injection) is available as a sterile, clear, colorless aqueous solution for intravenous injection. Mectorol Injection is supplied as either 4 mcg/2mL or 2 mcg/mL each in a stoppered, single use 2 mL amber glass vial, with an aluminum seal and yellow (4 mcg/2mL) or green (2 mcg/mL) flip-off cap. Each milliliter (mL) of solution contains doxercalciferol, 2 meg; ethanol, 100%, 0.05 mL; Polysorbate 20,10 mg; sodium chloride, 1.5 mg; butylated hydroxytoluene, 0.02 mg; sodium phosphate dibasic, heptahydrate, 14.4 mg; sodium phosphate monobasic, monohydrate, 1.8 mg; and disodium edetate, 1.1 mg.

Doxercalciferol is a colorless crystalline compound with a calculated molecular weight of 412.66 and a molecular formula of C28H44O2. It is soluble in oils and organic solvents, but is relatively insoluble in water. Chemically, doxercalciferol is (1α,3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diol and has the structural formula presented in Figure 1.

Figure 1: Chemical Structure of Doxercalciferol

HECTOROL (doxercalciferol) structural formula illustration

Other names frequently used for doxercalciferol are 1a-hydroxyvitamin D2,1a-0H-D2, and 1a-hydroxy-ergocalciferol.

What are the possible side effects of doxercalciferol (Hectorol)?

If you experience any of the following serious side effects, stop taking doxercalciferol and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • an irregular heartbeat;
  • increased nighttime urination; or
  • abdominal pain.

Contact your doctor if you experience any of the following side effects:

  • nausea, vomiting, or decreased appetite;
  • dry...

Read All Potential Side Effects and See Pictures of Hectorol Injection »

Last reviewed on RxList: 1/24/2011
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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