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Administration of Hectorol (doxercalciferol injection) to patients in excess doses can cause hypercalcemia, hypercalciuria, hyperphosphatemia, and over-suppression of PTH secretion leading in certain cases to adynamic bone disease. High intake of calcium and phosphate concomitant with Hectorol (doxercalciferol injection) may lead to similar abnormalities. High levels of calcium in the dialysate bath may contribute to hypercalcemia.
Treatment of Hypercalcemia and Overdosage
General treatment of hypercalcemia (greater than 1 mg/dL above the upper limit of the normal range) consists of immediate suspension of Hectorol (doxercalciferol injection) therapy, institution of a low calcium diet, and withdrawal of calcium supplements. Serum calcium levels should be determined at least weekly until normocalcemia ensues. Hypercalcemia usually resolves in 2 to 7 days. When serum calcium levels have returned to within normal limits, Hectorol (doxercalciferol injection) therapy may be reinstituted at a dose that is at least 1 meg lower than prior therapy. Serum calcium levels should be obtained weekly after all dosage changes and during subsequent dosage titration. Persistent or markedly elevated serum calcium levels may be corrected by dialysis against a reduced calcium or calcium-free dialysate.
Treatment of Accidental Overdosage of Hectorol (doxercalciferol injection)
The treatment of acute accidental overdosage of Hectorol (doxercalciferol injection) should consist of general supportive measures. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion, and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Such monitoring is critical in patients receiving digitalis. Discontinuation of supplemental calcium and institution of a low calcium diet are also indicated in accidental overdosage. If persistent and markedly elevated serum calcium levels occur, treatment with standard medical care should be followed, as needed. Based on similarities between Hectorol (doxercalciferol injection) and its active metabolite, 1a,25-(0H)2D2, it is expected that Hectorol (doxercalciferol injection) is not removed from the blood by dialysis.
Hectorol (doxercalciferol injection) should not be given to patients with a tendency towards hypercalcemia or current evidence of vitamin D toxicity.
Last reviewed on RxList: 1/24/2011
This monograph has been modified to include the generic and brand name in many instances.
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