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Hemabate Drug Center

Hemabate (carboprost tromethamine) Sterile Solution is used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Hemabate is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive. It is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Common side effects include mild fever that may come and go, chills, numbness, or tingly feeling, mild nausea or diarrhea, cough, headache, breast pain or tenderness, menstrual type pain, or ringing in your ears.

To treat refractory postpartum uterine bleeding, an initial dose of 250 mcg of Hemabate Sterile Solution (1 mL) is given deep, intramuscularly. For abortion and other indications, an initial dose of 1 mL (250 mcg) is administered deep in the muscle. Subsequent doses of 250 mcg are administered at 1½ to 3½ hour intervals depending on uterine response. Hemabate may interact with dinoprostone, mifepristone, misoprostol, or oxytocin. Tell your doctor all medications you are taking. During pregnancy, Hemabate should be used only if prescribed. There is no information on this medication and whether it passes into breast milk. Consult your doctor before breast-feeding.

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