Recommended Topic Related To:

Hepflush

"The U.S. Food and Drug Administration today approved Clinolipid (lipid injectable emulsion, USP) for intravenous feeding (parenteral nutrition) in adult patients, providing a source of calories and essential fatty acids for adult patients who are"...

Hepflush 10

HEPFLUSH® -10
(heparin lock flush solution), USP

FOR MAINTENANCE OF PATENCY OF INTRAVENOUS INJECTION DEVICES ONLY.
NOT FOR ANTICOAGULANT THERAPY.

DERIVED FROM PORCINE INTESTINAL MUCOSA.

PRESERVATIVE FREE.

DRUG DESCRIPTION

Heparin is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans having anticoagulant properties. Although others may be present, the main sugars occurring in heparin are: (1)α -L-iduronic acid 2-sulfate, (2) 2-deoxy-2-sulfamino-α -D-glucose 6-sulfate, (3) β-D-glu-curonic acid, (4) 2-acetamido-2-deoxy-α -D-glucose and (5)α -L-iduronic acid. These sugars are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions.

Heparin Lock Flush Solution, USP is a sterile preparation of heparin sodium derived from porcine intestinal mucosa, standardized for anticoagulant activity, with sufficient sodium chloride to make it isotonic with blood. The potency is determined by a biological assay using a USP reference standard based on units of heparin activity per milligram. Structure of Heparin Sodium (representative subunits):

Heparin Sodium Structural Formula Illustration

Each mL contains: 10 USP Units Heparin sodium (porcine); 9 mg sodium chloride; Water for Injection q.s. Sodium hydroxide and/or hydrochloric acid for pH adjustment (5.0-7.5).

Last reviewed on RxList: 3/5/2009
This monograph has been modified to include the generic and brand name in many instances.

A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations