"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(heparin lock flush solution), USP
FOR MAINTENANCE OF PATENCY OF INTRAVENOUS INJECTION DEVICES ONLY.
NOT FOR ANTICOAGULANT THERAPY.
DERIVED FROM PORCINE INTESTINAL MUCOSA.
Heparin is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans having anticoagulant properties. Although others may be present, the main sugars occurring in heparin are: (1)α -L-iduronic acid 2-sulfate, (2) 2-deoxy-2-sulfamino-α -D-glucose 6-sulfate, (3) β-D-glu-curonic acid, (4) 2-acetamido-2-deoxy-α -D-glucose and (5)α -L-iduronic acid. These sugars are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions.
Heparin Lock Flush Solution, USP is a sterile preparation of heparin sodium derived from porcine intestinal mucosa, standardized for anticoagulant activity, with sufficient sodium chloride to make it isotonic with blood. The potency is determined by a biological assay using a USP reference standard based on units of heparin activity per milligram. Structure of Heparin Sodium (representative subunits):
Each mL contains: 10 USP Units Heparin sodium (porcine); 9 mg sodium chloride; Water for Injection q.s. Sodium hydroxide and/or hydrochloric acid for pH adjustment (5.0-7.5).
Last reviewed on RxList: 3/5/2009
This monograph has been modified to include the generic and brand name in many instances.
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