"The U.S. Food and Drug Administration today granted accelerated approval to Lynparza (olaparib), a new drug treatment for women with advanced ovarian cancer associated with defective BRCA genes, as detected by an FDA-approved test.
No case of acute overdosage in humans has been described. The oral LD50 dose in rats was 1050 mg/kg and 437 mg/kg in mice.
HEXALEN® (altretamine) capsules is contraindicated in patients who have shown hypersensitivity to it. HEXALEN® (altretamine) capsules should not be employed in patients with preexisting severe bone marrow depression or severe neurologic toxicity. HEXALEN® (altretamine) capsules has been administered safely, however, to patients heavily pretreated with cisplatin and/or alkylating agents, including patients with preexisting cisplatin neuropathies. Careful monitoring of neurologic function in these patients is essential.
Last reviewed on RxList: 10/9/2008
This monograph has been modified to include the generic and brand name in many instances.
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