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High Blood Pressure Treatment (cont.)

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Can high blood pressure be prevented?

High blood pressure can sometimes be prevented if individuals follow a healthy lifestyle and:

Maintain a healthy weight. Being overweight can make a person two to six times more likely to develop high blood pressure.

Get regular exercise. Physically active people have up to a 50% lower risk of getting high blood pressure than people who are not active.

Reduce salt intake. Less than 4 grams per day is the goal.

Drink alcohol in moderation, or not at all. Drinking too much alcohol can raise blood pressure. If a person drinks alcohol, they should limit it to no more than two drinks a day.

Reduce stress. Stress can raise blood pressure.

What's new in high blood pressure?

A novel approach to hypertension treatment has been found by studying a hormone that controls insect growth. Butterfly researchers identified and characterized epoxide hydrolase, an enzyme involved in a critical pathway in the breakdown of anti-inflammatory arachidonate metabolites called EETs, or epoxyeicosatrienoic acids. Other researchers found that inhibiting the breakdown of EETs reduced blood pressure in rodents. This newly discovered enzyme also reduced vascular inflammation and end-organ damage, the long-term effects of high blood pressure.

The oral form of the enzyme developed in this study, currently in clinical trials, reduced the most common type of high blood pressure in middle-aged individuals. Pharmaceutical companies in several countries have initiated programs using this enzyme to treat high blood pressure, inflammation, diabetes, pain, and other disorders.

A surgical procedure also is being tested in other countries to lower high blood pressure. The procedure involves disrupting the nerves to the kidney. A large trial of this did not demonstrate benefit in lowering blood pressure.

Medically reviewed by Robert J. Bryg, MD; Board Certified Internal Medicine with subspecialty in Cardiovascular Disease

REFERENCES:

Cunha, John P. "Cardene IV Side Effects Center." RxList. 4 Mar. 2011.

Cunha, John P. "Tekturna Side Effects Center." RxList. 2 May 2012.

Imig, J. D., et al. "An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension." Hypertension46.4 (2005): 975-981.

Krum, H., et al. "Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study." Lancet 373.9671 (2009): 1275-1281.

Materson, B. J. and R. A. Preston. "Angiotensin-converting enzyme inhibitors in hypertension. A dozen years of experience." Archives of Internal Medicine 154.5 (1994): 513-523.

Stier Jr., C. T. "Eplerenone: a selective aldosterone blocker." Cardiovascular Drug Reviews 21.3 (2003): 169-184.

"Classification of Overweight and Obesity by BMI, Waist Circumference, and Associated Disease Risks." National Heart, Lung, and Blood Institute. 11 Oct. 2012.

"FDA Drug Safety Communication: New Warning and Contraindication for blood pressure medicines containing aliskiren (Tekturna)." U.S. Food and Drug Administration. 20 Apr. 2012.

"Inspra." RxList. 23 July 2012.

"Therapeutic Lifestyle Changes (TLC)." NIH.

"Understanding Your Risk for High Blood Pressure." American Heart Association. 27 Aug. 2012.

"Your Guide to Lowering Your Blood Pressure With DASH." National Heart, Lung, and Blood Institute. April 2006.

Previous contributing author: Dwight Makoff, MD


Medically Reviewed by a Doctor on 10/9/2014

Patient Comments

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High Blood Pressure Treatment - Experience Question: What kinds of treatments have been effective for your high blood pressure?
High Blood Pressure Treatment - Diet Question: How did you change your diet to lower your blood pressure?
High Blood Pressure Treatment - Smoking Question: Are you a smoker or former smoker undergoing treatment for high blood pressure? After diagnosis, did you quit smoking?
High Blood Pressure Treatment - Alcohol Question: Do you have hypertension and also drink alcohol? Have you cut back since receiving a diagnosis?
High Blood Pressure Treatment - Coffee and Caffeine Question: In what ways do coffee and other caffeinated beverages affect your blood pressure?
High Blood Pressure Treatment - Medications Question: What medications and other types of treatment do you receive for hypertension?
High Blood Pressure Treatment - Alternative Medicine Question: Describe any alternative or complementary medicine you use to treat your high blood pressure.
Source: MedicineNet.com
http://www.medicinenet.com/high_blood_pressure_treatment/article.htm

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