Horizant (gabapentin enacarbil) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Horizant

Restless Leg Syndrome »

What is restless leg syndrome (RLS)?

Restless leg syndrome (RLS, restless legs syndrome) is a common cause of painful legs. The leg pain of restless leg syndrome typically eases with motion of the legs and becomes more noticeable at rest. Restless leg syndrome also features worsening of symptoms and leg pain during the early evening or later at night.

Restless leg syndrome is often abbreviated RLS; it has also been termed shaking leg syndrome. Nighttime involuntary jerking of the legs during sleep are also known as periodic leg/limb movement disorder.

What causes restless leg syndrome?

The cause of restless leg syndrome is unknown in most people. However, restless leg syndrome has been associated with

pregnancy,
obesity,
smoking,
iron deficiency and anemia,
nerve disease,
polyneuropathy (which can be associated with hypothyroidism, heavy ...

Read the Restless Leg Syndrome article »

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Horizant User Reviews >>

Horizant

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HORIZANT
(gabapentin enacarbil)

DRUG DESCRIPTION

HORIZANT (gabapentin enacarbil) is a prodrug of gabapentin. Gabapentin enacarbil is described as (1-{[({(1JRS)-1-[(2-Methylpropanoyl)oxy]ethoxy}carbonyl)amino]methyl} cyclohexyl) acetic acid. It has a molecular formula of C₁₆H₂₇NO₆ and a molecular weight of 329.39. It is a racemate and has the following structural formula:

HORIZANT (gabapentin enacarbil) Structural Formula Illustration

Gabapentin enacarbil is a white to off-white crystalline solid with a melting onset of approximately 64°C and a solubility of 0.5 mg/mL in water and 10.2 mg/mL in phosphate buffer (pH 6.3).

HORIZANT is administered orally. Each HORIZANT Extended-Release Tablet contains 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, sodium lauryl sulfate, and talc. The 300 mg tablets also contain red ferric oxide.

What are the precautions when taking gabapentin enacarbil (Horizant)?

Before taking gabapentin enacarbil, tell your doctor or pharmacist if you are allergic to it; or to gabapentin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, mental/mood problems (such as depression, thoughts of suicide).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the...

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Last reviewed on RxList: 4/27/2012
This monograph has been modified to include the generic and brand name in many instances.