November 28, 2015
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H.P. Acthar Gel

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H.P. Acthar Gel

H.P. Acthar Gel
(repository corticotropin) Injection, Gel for Intramuscular or Subcutaneous Use


H.P. Acthar Gel is a highly purified sterile preparation of the adrenocorticotropic hormone in 16% gelatin to provide a prolonged release after intramuscular or subcutaneous injection. Also contains 0.5% phenol, not more than 0.1% cysteine (added), sodium hydroxide and/or acetic acid to adjust pH and water for injection.

ACTH is a 39 amino acid peptide with the following chemical formula:

H- Ser- Tyr- Ser- Met- Glu- His- Phe- Arg- Trp- Gly-
  1 2 3 4 5 6 7 8 9 10
  Lys- Pro- Val- Gly- Lys- Lys- Arg- Arg- Pro- Val-
  11 12 13 14 15 16 17 18 19 20
  Lys- Val- Try- Pro- Asp- Gly- Ala- Glu- Asp- Gln-
  21 22 23 24 25 26 27 28 29 30
  Leu- Ala- Glu- Ala- Phe- Pro- Leu- Glu- Phe- OH
  31 32 33 34 35 36 37 38 39

What are the possible side effects of corticotropin (Acthar Gel, H.P.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • problems with your vision;
  • swelling, rapid weight gain, feeling short of breath;
  • severe depression, unusual thoughts or behavior, seizure (convulsions);
  • bloody or tarry stools, coughing up blood;
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart...

Read All Potential Side Effects and See Pictures of H.P. Acthar Gel »

Last reviewed on RxList: 10/30/2012
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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