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H.P. Acthar Gel

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H.P. Acthar Gel

H.P. Acthar Gel
(repository corticotropin) Injection, Gel for Intramuscular or Subcutaneous Use

DRUG DESCRIPTION

H.P. Acthar Gel is a highly purified sterile preparation of the adrenocorticotropic hormone in 16% gelatin to provide a prolonged release after intramuscular or subcutaneous injection. Also contains 0.5% phenol, not more than 0.1% cysteine (added), sodium hydroxide and/or acetic acid to adjust pH and water for injection.

ACTH is a 39 amino acid peptide with the following chemical formula:

H- Ser- Tyr- Ser- Met- Glu- His- Phe- Arg- Trp- Gly-
  1 2 3 4 5 6 7 8 9 10
  Lys- Pro- Val- Gly- Lys- Lys- Arg- Arg- Pro- Val-
  11 12 13 14 15 16 17 18 19 20
  Lys- Val- Try- Pro- Asp- Gly- Ala- Glu- Asp- Gln-
  21 22 23 24 25 26 27 28 29 30
  Leu- Ala- Glu- Ala- Phe- Pro- Leu- Glu- Phe- OH
  31 32 33 34 35 36 37 38 39

What are the possible side effects of corticotropin (Acthar Gel, H.P.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • problems with your vision;
  • swelling, rapid weight gain, feeling short of breath;
  • severe depression, unusual thoughts or behavior, seizure (convulsions);
  • bloody or tarry stools, coughing up blood;
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart...

Read All Potential Side Effects and See Pictures of H.P. Acthar Gel »

Last reviewed on RxList: 10/30/2012
This monograph has been modified to include the generic and brand name in many instances.

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