In this Article

• What is insulin lispro and insulin lispro protamine (Humalog Mix 50-50)?
• What are the possible side effects of insulin lispro and insulin lispro protamine?
• What is the most important information I should know about insulin lispro and insulin lispro protamine?
• What should I discuss with my healthcare provider before using insulin lispro and insulin lispro protamine?
• How should I use insulin lispro and insulin lispro protamine?
• What happens if I miss a dose?
• What happens if I overdose?
• What should I avoid while using insulin lispro and insulin lispro protamine?
• What other drugs will affect insulin lispro and insulin lispro protamine?
• Where can I get more information?

What happens if I miss a dose?

Since this medication is used before meals, you may not be on a timed dosing schedule. Whenever you use insulin lispro and insulin lispro protamine, be sure to eat a meal within 15 minutes. Do not use extra insulin lispro and insulin lispro protamine to make up a missed dose.

Keep insulin lispro and insulin lispro protamine on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What should I avoid while using insulin lispro and insulin lispro protamine?

Avoid drinking alcohol. It can lower your blood sugar.

Do not expose insulin lispro and insulin lispro protamine to high heat.

What other drugs will affect insulin lispro and insulin lispro protamine?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• albuterol (Proventil, Ventolin);
• clonidine (Catapres);
• reserpine; or
• beta-blockers such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

Where can I get more information?

Your pharmacist can provide more information about insulin lispro and insulin lispro protamine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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