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Somatropin (rDNA origin) for Injection CARTRIDGES

HUMATROPE (somatropin rdna origin) CARTRIDGES ARE ONLY TO BE USED WITH HUMATROPE (somatropin rdna origin) N® OR HUMATROPE (somatropin rdna origin) N® 3 INJECTION DEVICES.

Important Things to Know

It is important to learn the names of the parts of the Humatrope (somatropin rdna origin) Cartridge Kit and how these parts work before injecting yourself or your child. Make sure you have been properly trained by your nurse, pharmacist or doctor before you mix the drug (add the diluent liquid to the dry Humatrope (somatropin rdna origin) powder) or inject it. Wash your hands and be careful to follow the instructions given to you by your nurse, pharmacist or doctor. After mixing, throw away the diluent syringe in a puncture-resistant container such as the type your nurse, pharmacist or doctor has told you to use.


Humatrope (somatropin rdna origin) must be kept refrigerated (36° to 46°F [2° to 8°C]) before and after it is mixed. Do not freeze. Once Humatrope (somatropin rdna origin) has been mixed and is in liquid form, it must be used within 28 days. Throw away any mixed Humatrope (somatropin rdna origin) left over after 28 days. Before giving an injection, check the date on the cartridge. Do not use the cartridge if it has expired.




  • one cartridge with 6, 12, or 24 mg of dried Humatrope (somatropin rdna origin)
  • one prefilled syringe with diluent (the liquid used to mix the dried Humatrope (somatropin rdna origin) )

NOTE: There are three kinds of Humatrope (somatropin rdna origin) cartridges that have different amounts of Humatrope (somatropin rdna origin) (6, 12, or 24 mg). Make sure that you have the cartridge that your doctor prescribed.

Mixing the Humatrope (somatropin rdna origin) in the Cartridge

Use only the prefilled diluent syringe to mix the Humatrope (somatropin rdna origin) in the cartridge. DO NOT use the diluent that comes in the Humatrope (somatropin rdna origin) vial box, or any other liquid.

Reconstitution Instructions


Parts of the cartridge - illustration

Use only this kit to prepare the Humatrope (somatropin rdna origin) cartridge.
*Note: The liquid is colorless.
It is shown here as blue for illustration purposes only.

Preparing Your New Cartridge

Tray contents - illustration

Remove ALL contents from the tray.
Note: This product is designed for left or right handed use so you may use whichever hand is most comfortable for you.

Grasp the gray Needle Cover - illustration

Grasp the gray Needle Cover, at the bottom of the Diluent Syringe.

Remove the Needle Cover  - illustration

Remove the Needle Cover and discard. DO NOT depress the Plunger yet. It is okay if a drop of fluid is lost. It is not necessary to release air from the Diluent Syringe.

Align the cartridge and Diluent Syringe - illustration

Hold the cartridge, with the Black Triangles toward the Diluent Syringe. Align the cartridge and Diluent Syringe in a straight line. DO NOT insert the cartridge at an angle.

PUSH the cartridge STRAIGHT in - illustration

PUSH the cartridge STRAIGHT in until it stops AND the Black Triangles ARE COVERED. You may hear or feel a click. DO NOT twist the cartridge.

Hold the Diluent Syringe and the cartridge together - illustration

Hold the Diluent Syringe and the cartridge together with TWO HANDS. Push and release the Plunger 2 or 3 times until the Diluent is in the cartridge.

Remove your thumb from the Plunger - illustration

Remove your thumb from the Plunger and check that the Diluent Syringe is empty [it is normal for small drops of Diluent to remain in the Diluent Syringe].

Pull the cartridge away from the Diluent Syringe - illustration

With your thumb OFF the Plunger, pull the cartridge away from the Diluent Syringe.

Place the End Cap on a hard, flat surface - illustration

Place the End Cap on a hard, flat surface. Push the Diluent Syringe onto the End Cap and immediately discard the Diluent Syringe as instructed by your healthcare professional.

Mix the cartridge by gently inverting 10 times - illustration

Mix the cartridge by gently inverting 10 times and let it sit for 3 minutes, DO NOT SHAKE.

Inspect the solution - illustration

Inspect the solution. The Humatrope (somatropin rdna origin) solution should be clear.
If the solution is clear, your cartridge is now prepared and ready to be attached to your pen injection device (see the User Manual for your pen injection device).
If the solution is cloudy or contains particles, gently invert the cartridge 10 additional times.
Let the cartridge sit for 5 more minutes. If the solution remains cloudy or contains particles,
Contact your healthcare professional or Lilly. If you have questions about preparing your Humatrope (somatropin rdna origin) cartridge, you should contact your Humatrope (somatropin rdna origin) provider or your healthcare professional.

Injections can be given in the following areas:

  • Abdomen (above, below, or either side of the navel)
  • Front of the upper thighs
  • Upper, outer buttocks
  • Back of the arms above the elbow and below the shoulder

Discuss use of the pen injection device, the right places to inject, and site rotation with your nurse or doctor.

Literature revised August 1, 2005

Last reviewed on RxList: 8/18/2010
This monograph has been modified to include the generic and brand name in many instances.


Humatrope - User Reviews

Humatrope User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Humatrope sorted by most helpful. Patient Discussions FAQs

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