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Humorsol

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Humorsol

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Humorsol Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Humorsol (demecarium bromide) Ophthalmic Solution is a cholinesterase inhibitor used to treat glaucoma by lowering the pressure inside the eye. Humorsol ophthalmic is also used for other conditions that require increased fluid outflow from the eye, after surgical iridectomy, and for certain eye disorders involving eye accommodation (focusing). The brand name of this medication is discontinued, but generic versions may be available. Common side effects include burning, stinging, red, or tearing eyes; eyelid muscle twitches; headache or brow ache; or decreased vision in poor light.

For initial therapy with Humorsol (0.125 percent or 0.25 percent) place 1 drop (children) or 1 or 2 drops (adults) in the affected eye. Humorsol may interact with other eye medications, or organophosphates (such as those used in gardening). Tell your doctor all medications and supplements you use. Humorsol is known to cause birth defects in a fetus. Do not use Humorsol ophthalmic if you are pregnant or could become pregnant during treatment. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Humorsol (demecarium bromide) Ophthalmic Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Humorsol FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Stinging, burning, lacrimation, lid muscle twitching, conjunctival and ciliary redness, brow ache, headache, and induced myopia with visual blurring may occur.

Activation of latent iritis or uveitis may occur.

As with all miotic therapy, retinal detachment has been reported occasionally.

Iris cysts may form, enlarge, and obscure vision. Occurrence is more frequent in children. The iris cyst usually shrinks upon discontinuance of the miotic. Rarely, the cyst may rupture or break free into the aqueous. Frequent examination for this occurrence is advised.

Lens opacities have been reported in patients on miotic therapy. Routine slit-lamp examinations, including the lens, should accompany prolonged use.

Paradoxical increase in intraocular pressure may follow anticholinesterase instillation. This may be alleviated by pupil-dilating medication.

Prolonged use may cause conjunctival thickening and obstruction of nasolacrimal canals.

Systemic effects, which occur rarely, are suggestive of increased cholinergic activity. Such effects may include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities. Medical management of systemic effects may be indicated (see TREATMENT OF ADVERSE EFFECTS ).

TREATMENT OF ADVERSE EFFECTS

If HUMORSOL (demecarium) is taken systemically by accident, or if systemic effects occur after topical application in the eye or from accidental skin contact, administer atropine sulfate parenterally (intravenously if necessary) in a dose (for adults) of 0.4 to 0.6 mg or more. The recommended dosage of atropine in infants and children up to 12 years of age is 0.01 mg/kg repeated every two hours as needed until the desired effect is obtained, or adverse effects of atropine preclude further usage. The maximum single dose should not exceed 0.4 mg.

The use of much larger doses of atropine in treating anticholinesterase intoxication in adults has been reported in the literature. Initially 2 to 6 mg may be given followed by 2 mg every hour or more often, as long as muscarinic effects continue. The greater possibility of atropinization with large doses, particularly in sensitive individuals, should be borne in mind.

Pralidoxime** chloride has been reported to be useful in treating systemic effects due to cholinesterase inhibitors. However, its use is recommended in addition to and not as substitute for atropine.

A short-acting barbiturate is indicated if convulsions occur that are not entirely relieved by atropine. Barbiturate dosage should be carefully adjusted to avoid central respiratory depression. Marked weakness or paralysis of muscles of respiration should be treated promptly by artificial respiration and maintenance of a clear airway.

The oral LD 50 of HUMORSOL (demecarium) is 2.96 mg/kg in the mouse.

**PROTOPAM® Chloride (Pralidoxime Chloride). Ayerst Laboratories

Read the entire FDA prescribing information for Humorsol (Demecarium) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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