May 1, 2017
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Humulin 50-50

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Humulin 50-50

How Supplied


No information provided.


Your doctor has told you which insulin to use, how much, and when and how often to inject it. Because each patient's diabetes is different, this schedule has been individualized for you. Your usual dose of Humulin 50/50 may be affected by changes in your diet, activity, or work schedule. Carefully follow your doctor's instructions to allow for these changes. Other things that may affect your Humulin 50/50 dose are:


Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you will still require insulin. You and your doctor should establish a sick day plan for you to use in case of illness. When you are sick, test your blood glucose frequently. If instructed by your doctor, test your ketones and report the results to your doctor.


Good control of diabetes is especially important for you and your unborn baby. Pregnancy may make managing your diabetes more difficult. If you are planning to have a baby, are pregnant, or are nursing a baby, talk to your doctor.


Insulin requirements may be increased if you are taking other drugs with blood-glucose-raising activity, such as oral contraceptives, corticosteroids, or thyroid replacement therapy. Insulin requirements may be reduced in the presence of drugs that lower blood glucose or affect how your body responds to insulin, such as oral antidiabetic agents, salicylates (for example, aspirin), sulfa antibiotics, alcohol, certain antidepressants and some kidney and blood pressure medicines.

Your Healthcare Professional may be aware of other medications that may affect your diabetes control. Therefore, always discuss any medications you are taking with your doctor.


Exercise may lower your body's need for insulin during and for some time after the physical activity. Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of injection site (for example, the leg should not be used for injection just prior to running). Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.


When traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.



Human insulin from Eli Lilly and Company has the trademark Humulin. Your doctor has prescribed the type of insulin that he/she believes is best for you.


Always check the carton and the bottle label for the name and letter designation of the insulin you receive from your pharmacy to make sure it is the same as prescribed by your doctor.

Always check the appearance of your bottle of Humulin 50/50 before withdrawing each dose. Before each injection the Humulin 50/50 bottle must be carefully shaken or rotated several times to completely mix the insulin. Humulin 50/50 suspension should look uniformly cloudy or milky after mixing. If not, repeat the above steps until contents are mixed.

Do not use Humulin 50/50:

  • if the insulin substance (the white material) remains at the bottom of the bottle after mixing or
  • if there are clumps in the insulin after mixing, or
  • if solid white particles stick to the bottom or wall of the bottle, giving a frosted appearance.

If you see anything unusual in the appearance of Humulin 50/50 suspension in your bottle or notice your insulin requirements changing, talk to your doctor.


Not in-use (unopened): Humulin 50/50 bottles not in-use should be stored in a refrigerator, but not in the freezer.

In-use (opened): The Humulin 50/50 bottle you are currently using can be kept unrefrigerated as long as it is kept as cool as possible [below 86°F (30°C)] away from heat and light.

Do not use Humulin 50/50 after the expiration date stamped on the label or if it has been frozen.



Correct Syringe Type

Doses of insulin are measured in units. U-100 insulin contains 100 units/mL (1 mL=1 cc). With Humulin 50/50, it is important to use a syringe that is marked for U-100 insulin preparations. Failure to use the proper syringe can lead to a mistake in dosage, causing serious problems for you, such as a blood glucose level that is too low or too high.

Syringe Use

To help avoid contamination and possible infection, follow these instructions exactly.

Disposable syringes and needles should be used only once and then discarded by placing the used needle in a puncture-resistant disposable container. Properly dispose of the puncture-resistant container as directed by your Health Care Professional.

Preparing the Dose
  1. Wash your hands.
  2. Carefully shake or rotate the bottle of insulin several times to completely mix the insulin.
  3. Inspect the insulin. Humulin 50/50 suspension should look uniformly cloudy or milky. Do not use Humulin 50/50 if you notice anything unusual in its appearance.
  4. If using a new Humulin 50/50 bottle, flip off the plastic protective cap, but do not remove the stopper. Wipe the top of the bottle with an alcohol swab.
  5. Draw an amount of air into the syringe that is equal to the Humulin 50/50 dose. Put the needle through rubber top of the Humulin 50/50 bottle and inject the air into the bottle.
  6. Turn the Humulin 50/50 bottle and syringe upside down. Hold the bottle and syringe firmly in one hand and shake gently.
  7. Making sure the tip of the needle is in the Humulin 50/50 suspension, withdraw the correct dose of Humulin 50/50 into the syringe.
  8. Before removing the needle from the Humulin 50/50 bottle, check the syringe for air bubbles. If bubbles are present, hold the syringe straight up and tap its side until the bubbles float to the top. Push the bubbles out with the plunger and then withdraw the correct dose.
  9. Remove the needle from the bottle and lay the syringe down so that the needle does not touch anything.
Injection Instructions
  1. To avoid tissue damage, choose a site for each injection that is at least ½ inch from the previous injection site. The usual sites of injection are abdomen, thighs, and arms.
  2. Cleanse the skin with alcohol where the injection is to be made.
  3. With one hand, stabilize the skin by spreading it or pinching up a large area.
  4. Insert the needle as instructed by your doctor.
  5. Push the plunger in as far as it will go.
  6. Pull the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area.
  7. Place the used needle in a puncture-resistant disposable container and properly dispose of the puncture-resistant container as directed by your Health Care Professional.


Information about diabetes may be obtained from your diabetes educator.

Additional information about diabetes and Humulin can be obtained by calling The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or by visiting
Vials manufactured by : Eli Lilly and Company, Indianapolis, IN 46285, USA or Lilly France, F-67640 Fegersheim, France for Eli Lilly and Company, Indianapolis, IN 46285, USA. FDA rev date: 8/22/2007

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 1/25/2017

How Supplied

Humulin 50-50 - User Reviews

Humulin 50-50 User Reviews

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