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Humulin 70-30

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Humulin 70-30

Humulin 70-30

INDICATIONS

HUMULIN 70/30 is a fixed ratio premix recombinant human insulin formulation indicated to improve glycemic control in adult patients with diabetes mellitus.

DOSAGE AND ADMINISTRATION

Important Administration Instructions

Inspect HUMULIN 70/30 visually before use. It should not contain particulate matter and should appear uniformly cloudy after mixing. Do not use HUMULIN 70/30 if particulate matter is seen. Do not mix HUMULIN 70/30 with any other insulins or diluents.

Route Of Administration

HUMULIN 70/30 should only be administered subcutaneously. Administer in the subcutaneous tissue of the abdominal wall, thigh, upper arm, or buttocks. To reduce the risk of lipodystrophy, rotate the injection site within the same region from one injection to the next [see ADVERSE REACTIONS].

Do not administer HUMULIN 70/30 intravenously or intramuscularly and do not use HUMULIN 70/30 in an insulin infusion pump.

Dosage Information

Individualize and adjust the dosage of HUMULIN 70/30 based on the individual's metabolic needs, blood glucose monitoring results and glycemic control goal. Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness [see WARNINGS AND PRECAUTIONS, and Use in Specific Populations].

The proportion of rapid acting and long acting insulin is fixed in a premixed insulin such as HUMULIN 70/30. Independent adjustment of the basal or prandial dose is not possible when using a premixed insulin.

Physiological factors, disease states and concomitant drugs may impact the onset and duration of action of all insulins. HUMULIN 70/30 dose requirements may change with changes in level of physical activity, meal patterns (i.e., macronutrient content or timing of food intake), during major illness, or with some coadministered drugs [see WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS, and Use In Specific Populations].

Timing Of Subcutaneous Administration

HUMULIN 70/30 should be given subcutaneously approximately 30-45 minutes before a meal.

HOW SUPPLIED

Dosage Forms And Strengths

HUMULIN 70/30 injectable suspension: 100 units per mL (U-100) is available as:

  • 10 mL vials
  • 3 mL vials
  • 3 mL prefilled pens

HUMULIN 70/30 100 units per mL (U-100) is available as:

10 mL vials NDC 0002-8715-01 (HI-710)
3 mL vials NDC 0002-8715-17 (HI-713)
5 x 3 mL prefilled pen NDC 0002-8770-59 (HP-8770)

Storage And Handling

Protect from heat and light. Do not freeze. Do not use after the expiration date.

Not In-Use (Unopened) HUMULIN 70/30 Vials
Refrigerated

Store in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. Do not use if it has been frozen.

Room Temperature

If stored at room temperature, below 86°F (30°C) the vial must be discarded after 31days.

In-Use (Opened) HUMULIN 70/30 Vials

Refrigerated

Store in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. Do not use if it has been frozen. Vials must be used within 31 days or be discarded, even if they still contain HUMULIN 70/30.

Room Temperature

If stored at room temperature, below 86°F (30°C) the vial must be discarded after 31 days, even if the vial still contains HUMULIN 70/30.

Not In-Use (Unopened) HUMULIN 70/30 Pen

Refrigerated

Store in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. Do not use if it has been frozen.

Room Temperature

If stored at room temperature, below 86°F (30°C) the pen must be discarded after 10 days.

In-Use (Opened) HUMULIN 70/30 Pen

Refrigerated

Do NOT store in a refrigerator.

Room Temperature

Store at room temperature, below 86°F (30°C) and the pen must be discarded after 10 days, even if the pen still contains HUMULIN 70/30. See storage table below:

  Not In-Use (Unopened) Refrigerated Not In-Use (Unopened) Room Temperature In-Use (Opened)
10 mL vial 3 mL vial Until expiration date 31 days 31 days, refrigerated/room temperature
3 mL pen Until expiration date 10 days 10 days, room temperature. Do not refrigerate.

Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA. Revised: Nov 2013

Last reviewed on RxList: 1/27/2014
This monograph has been modified to include the generic and brand name in many instances.

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