May 24, 2017
Recommended Topic Related To:

Hycamtin Capsules

"The US Food and Drug Administration (FDA) has approved the immunotherapy drug atezolizumab (Tecentriq, Genentech) for use in patients with metastatic non-small cell lung cancer (NSCLC) who have progressed during or after treatment with a"...


Hycamtin Capsules

(topotecan) Capsules



HYCAMTIN can cause severe myelosuppression. Administer only to patients with neutrophil counts of ≥ 1,500 cells/mm³ and platelet counts ≥ 100,000 cells/mm³. Monitor blood cell counts.


Topotecan hydrochloride is a semi-synthetic derivative of camptothecin and is an anti-tumor drug with topoisomerase I-inhibitory activity.

The chemical name for topotecan hydrochloride is (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1#-pyrano[3',4': 6,7] indolizino [1,2-6]quinoline-3,14-(4#,12#)-dione monohydrochloride. It has the molecular formula C23H23N3O5•HCl and a molecular weight of 457.9. It is soluble in water and melts with decomposition at 213° to 218°C.

Topotecan hydrochloride has the following structural formula:

HYCAMTIN (topotecan) Structural Formula Illustration

HYCAMTIN capsules for oral use contain topotecan hydrochloride, the content of which is expressed as topotecan free base. The excipients are gelatin, glyceryl monostearate, hydrogenated vegetable oil, and titanium dioxide. The capsules are imprinted with edible black ink. The 1-mg capsules also contain red iron oxide.

What are the possible side effects of topotecan (Hycamtin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • wheezing, feeling short of breath, chest pain, dry cough;
  • fever, chills, flu symptoms, mouth and throat ulcers, rapid and shallow breathing, fainting;
  • pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots...

Read All Potential Side Effects and See Pictures of Hycamtin Capsules »

Last reviewed on RxList: 12/8/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get the latest treatment options.

Related Drugs
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations