In this Article

• What is topotecan (Hycamtin)?
• What are the possible side effects of topotecan (Hycamtin)?
• What is the most important information I should know about topotecan (Hycamtin)?
• What should I discuss with my healthcare provider before using topotecan (Hycamtin)?
• How should I use topotecan (Hycamtin)?
• What happens if I miss a dose (Hycamtin)?
• What happens if I overdose (Hycamtin)?
• What should I avoid while using topotecan (Hycamtin)?
• What other drugs will affect topotecan (Hycamtin)?
• Where can I get more information?

What happens if I miss a dose (Hycamtin)?

Call your doctor for instructions if you miss any of your topotecan doses.

What happens if I overdose (Hycamtin)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause bone marrow depression (fever, chills, body aches, flu symptoms, sores or white patches in your mouth, or other signs of infection).

What should I avoid while using topotecan (Hycamtin)?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using topotecan, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), oral polio, typhoid, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine.

Topotecan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect topotecan (Hycamtin)?

Tell your doctor about all other cancer medicines you use, especially:

• filgrastim (Neupogen), pegfilgrastim (Neulasta), or sargramostim (Leukine); or
• cisplatin (Platinol), carboplatin (Paraplatin), or oxaliplatin (Eloxatin).

This list is not complete and other drugs may interact with topotecan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about topotecan.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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