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(hydrocodone bitartrate and homatropine methylbromide) Tablets, Oral Solution



Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death (see WARNINGS, DRUG INTERACTIONS). Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol.


HYCODAN contains hydrocodone (dihydrocodeinone) bitartrate, a semisynthetic centrally-acting opioid antitussive. Homatropine methylbromide is included in a subtherapeutic amount to discourage deliberate overdosage.

Each HYCODAN tablet or teaspoonful (5 mL) contains:

Hydrocodone Bitartrate, USP 5 mg
Homatropine Methylbromide, USP 1.5 mg

HYCODAN tablets also contain: calcium phosphate dibasic, colloidal silicon dioxide, lactose, magnesium stearate, starch and stearic acid.

HYCODAN oral solution also contains: caramel coloring, FD&C Red 40, liquid sugar, methylparaben, propylparaben, sorbitol solution and wild cherry imitation flavor.

The hydrocodone component is 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5), a fine white crystal or crystalline powder, which is derived from the opium alkaloid, thebaine, has a molecular weight of (494.50), and may be represented by the following structural formula:

Hydrocodone Bitartrate - Structural  Formula Illustration 1

Homatropine methylbromide - Structural  Formula Illustration 2

Homatropine methylbromide is 8-Azoniabicyclo [3.2.1]octane,3-[(hydroxyphenyl-acetyl)oxy]-8,8dimethyl-,bromide, endo-; a white crystal or fine white crystalline powder, with a molecular weight of (370.29).

What are the possible side effects of homatropine and hydrocodone (Hycodan, Hydromet, Tussigon)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • painful urination;
  • urinating less than usual or not at all;
  • extreme drowsiness or weakness;
  • feeling like you might pass out;
  • weak or shallow breathing, or breathing that stops;
  • feeling anxious or fearful; or
  • unusual thoughts or...

Read All Potential Side Effects and See Pictures of Hycodan »

What are the precautions when taking hydrocodone bitartrate and homatropine methylbromide (Hycodan)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to hydrocodone; or to homatropine; or to other narcotic medications (such as codeine, hydromorphone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD, intoxication with medications that can cause drowsiness or slow/shallow breathing), gallbladder disease, kidney disease, liver disease, mental/mood disorders (such as confusion,...

Read All Potential Precautions of Hycodan »

Last reviewed on RxList: 1/30/2017
This monograph has been modified to include the generic and brand name in many instances.

Hycodan - User Reviews

Hycodan User Reviews

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Here is a collection of user reviews for the medication Hycodan sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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