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Acute mucocutaneous toxicity has been reported in patients receiving hydroxyurea at dosages several times the therapeutic dose. Soreness, violet erythema, edema on palms and soles followed by scaling of hands and feet, severe generalized hyperpigmentation of the skin, and stomatitis have also been observed.
Hydroxyurea is contraindicated in patients with marked bone marrow depression, i.e., leukopenia ( < 2500 WBC) or thrombocytopenia ( < 100,000), or severe anemia.
HYDREA (hydroxyurea) is contraindicated in patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/23/2010
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