"A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutat"...
Acute mucocutaneous toxicity has been reported in patients receiving hydroxyurea at dosages several times the therapeutic dose. Soreness, violet erythema, edema on palms and soles followed by scaling of hands and feet, severe generalized hyperpigmentation of the skin, and stomatitis have also been observed.
Hydroxyurea is contraindicated in patients with marked bone marrow depression, i.e., leukopenia ( < 2500 WBC) or thrombocytopenia ( < 100,000), or severe anemia.
HYDREA (hydroxyurea) is contraindicated in patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation.
Last reviewed on RxList: 6/23/2010
This monograph has been modified to include the generic and brand name in many instances.
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