Hyzaar (Losartan Potassium-Hydrochlorothiazide) Patient Information: How Should I Take the Drug at RxList

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May 27, 2012

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Angiotensin Receptor Blockers (ARBs) »

What are angiotensin receptor blockers (ARBs) and how do they work?

The class of drugs called angiotensin receptor blockers (ARBs), as the class name suggests, are drugs that block the action of angiotensin. Specifically, ARBs prevent angiotensin II from binding to the angiotensin II receptor on blood vessels and other tissues.

Angiotensin II is a very potent chemical that causes the muscles surrounding blood vessels to contract, thereby narrowing the blood vessels. Narrowing of blood vessels increases the pressure within the blood vessels and may lead to high blood pressure (hypertension). Reducing the binding and activity of angiotensin II leads to widening (dilation) of blood vessels and reduces blood pressure. By lowering blood pressure against which the heart must pump, the amount of work that the heart must do is reduced. ACE inhibitors also reduce blood pressure in the kidneys, slowing the progression of kidney disease due to high b...

Read the Angiotensin Receptor Blockers (ARBs) article »

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Hyzaar Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking hydrochlorothiazide and losartan (Hyzaar)?

Do not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take this medication:

kidney disease;
liver disease;
congestive heart failure;
asthma or allergies;
low or high levels of potassium in your blood;
gout;
lupus;
diabetes; or
an allergy to sulfa drugs.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. Losartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

It is not known whether hydrochlorothiazide and losartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and losartan (Hyzaar)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medication with a full glass (8 ounces) of water.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your kidney function may also need to be tested. Do not miss any scheduled appointments.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Store hydrochlorothiazide and losartan at room temperature away from moisture and heat.

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