Brand Names: Hyzaar

Generic Name: hydrochlorothiazide and losartan (Pronunciation: HYE droe KLOR oh THYE a zide and loe SAR tan)

• What is hydrochlorothiazide and losartan (Hyzaar)?
• What are the possible side effects of hydrochlorothiazide and losartan (Hyzaar)?
• What is the most important information I should know about hydrochlorothiazide and losartan (Hyzaar)?
• What should I discuss with my healthcare provider before taking hydrochlorothiazide and losartan (Hyzaar)?
• How should I take hydrochlorothiazide and losartan (Hyzaar)?
• What happens if I miss a dose (Hyzaar)?
• What happens if I overdose (Hyzaar)?
• What should I avoid while taking hydrochlorothiazide and losartan (Hyzaar)?
• What other drugs will affect hydrochlorothiazide and losartan (Hyzaar)?
• Where can I get more information?

What is hydrochlorothiazide and losartan (Hyzaar)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Losartan is an angiotensin II receptor antagonists. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of hydrochlorothiazide and losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.

Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.

HCTZ-Losartan 12.5-100 mg-TEV

oval, white, imprinted with 93, 7369

HCTZ-Losartan 12.5-50 mg-TEV

oval, yellow, imprinted with 93, 7367

HCTZ-Losartan 25-100 mg-TEV

oval, yellow, imprinted with 93, 7368

Hyzaar 12.5 mg-50 mg

oval, yellow, imprinted with 717

Hyzaar 12.5-100 mg

oval, white, imprinted with 745

Hyzaar 25 mg-100 mg

oval, yellow, imprinted with 747

Losartan-HCTZ 100-12.5 mg-ROX

round, white, imprinted with 54, 931

Losartan-HCTZ 100-25 mg-ROX

round, yellow, imprinted with 54 557

Losartan-HCTZ 50-12.5 mg-ROX

round, yellow, imprinted with 54 717

What are the possible side effects of hydrochlorothiazide and losartan (Hyzaar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

• eye pain, vision problems;
• feeling light-headed, fainting;
• swelling, rapid weight gain;
• fast or pounding heartbeats;
• pale skin, easy bruising or bleeding;
• urinating less than usual, or not at all;
• jaundice (yellowing of the skin or eyes); or
• dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, fainting, or seizure (convulsions).

Less serious side effects may include:

• stomach pain;
• back pain;
• dizziness, tired feeling;
• skin rash;
• runny or stuffy nose, sore throat; or
• dry cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Hyzaar (losartan potassium-hydrochlorothiazide) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about hydrochlorothiazide and losartan (Hyzaar)?

You should not use this medication if you are allergic to hydrochlorothiazide or losartan, or if you are unable to urinate.

Before using hydrochlorothiazide and losartan, tell your doctor if you have congestive heart failure, kidney or liver disease, glaucoma, asthma, low or high blood levels of potassium, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and losartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and losartan, unless your doctor has told you to.

In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.