April 23, 2017
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Ibrance

"Five fatal cases of neutropenic enterocolitis, inflammation of the mucosa of the small intestine and colon, have been reported in patients treated with docetaxel, French oncologists were informed in a letter dated February 15 by the A"...

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Ibrance

IBRANCE®
(palbociclib) Capsules

DRUG DESCRIPTION

IBRANCE capsules for oral administration contain 125 mg, 100 mg, or 75 mg of palbociclib, a kinase inhibitor. The molecular formula for palbociclib is C24H29N7O2. The molecular weight is 447.54 daltons. The chemical name is 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, and its structural formula is:

IBRANCE®(palbociclib) Structural Formula Illustration

Palbociclib is a yellow to orange powder with pKa of 7.4 (the secondary piperazine nitrogen) and 3.9 (the pyridine nitrogen). At or below pH 4, palbociclib behaves as a high-solubility compound. Above pH 4, the solubility of the drug substance reduces significantly.

Inactive Ingredients

Microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and hard gelatin capsule shells. The light orange, light orange/caramel, and caramel opaque capsule shells contain gelatin, red iron oxide, yellow iron oxide, and titanium dioxide; the printing ink contains shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone.

Last reviewed on RxList: 4/14/2017
This monograph has been modified to include the generic and brand name in many instances.

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