November 26, 2015
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Coronary vasospasm was observed after intravenous administration of IMITREX Injection [see CONTRAINDICATIONS]. Overdoses would be expected from animal data (dogs at 0.1 g/kg, rats at 2 g/kg) to possibly cause convulsions, tremor, inactivity, erythema of the extremities, reduced respiratory rate, cyanosis, ataxia, mydriasis, injection site reactions (desquamation, hair loss, and scab formation), and paralysis.

The elimination half-life of sumatriptan is about 2 hours [see CLINICAL PHARMACOLOGY]; therefore, monitoring of patients after overdose with IMITREX Injection should continue for at least 10 hours or while symptoms or signs persist.

It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan.


IMITREX Injection is contraindicated in patients with:

  • Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetal’s angina [see WARNINGS AND PRECAUTIONS].
  • Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders [see WARNINGS AND PRECAUTIONS].
  • History of stroke or transient ischemic attack (TIA) or history of hemiplegic or basilar migraine because these patients are at a higher risk of stroke [see WARNINGS AND PRECAUTIONS].
  • Peripheral vascular disease [see WARNINGS AND PRECAUTIONS].
  • Ischemic bowel disease [see WARNINGS AND PRECAUTIONS].
  • Uncontrolled hypertension [see WARNINGS AND PRECAUTIONS].
  • Recent use (i.e., within 24 hours) of ergotamine-containing medication, ergot-type medication (such as dihydroergotamine or methysergide), or another 5-hydroxytryptamine1 (5-HT1) agonist [see DRUG INTERACTIONS].
  • Concurrent administration of a monoamine oxidase (MAO)-A inhibitor or recent (within 2 weeks) use of an MAO-A inhibitor [see DRUG INTERACTIONS, CLINICAL PHARMACOLOGY].
  • Hypersensitivity to IMITREX (angioedema and anaphylaxis seen) [see WARNINGS AND PRECAUTIONS].
  • Severe hepatic impairment [see CLINICAL PHARMACOLOGY].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 7/1/2015


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