"March 1, 2013 -- People with celiac disease or inflammatory bowel disease appear to have more migraine headaches than people without the conditions, a new study shows.
Researcher Peter H. Green, MD, of Columbia University in New York,"...
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In cases of overdosage, (including relative overdose due to hepatic dysfunction), urinary retention, paralytic ileus and CNS depression may occur. Children may be more sensitive to CNS effects than adults. Clinical trials have demonstrated that a slurry of activated charcoal administered promptly after ingestion of loperamide hydrochloride can reduce the amount of drug which is absorbed into the systemic circulation by as much as ninefold. If vomiting occurs spontaneously upon ingestion, a slurry of 100 gms of activated charcoal should be administered orally as soon as fluids can be retained.
If vomiting has not occurred, gastric lavage should be performed followed by administration of 100 gms of the activated charcoal slurry through the gastric tube. In the event of overdosage, patients should be monitored for signs of CNS depression for at least 24 hours.
If symptoms of overdose occur, naloxone can be given as an antidote. If responsive to naloxone, vital signs must be monitored carefully for recurrence of symptoms of drug overdose for at least 24 hours after the last dose of naloxone.
In view of the prolonged action of loperamide and the short duration (one to three hours) of naloxone, the patient must be monitored closely and treated repeatedly with naloxone as indicated. Since relatively little drug is excreted in the urine, forced diuresis is not expected to be effective for IMODIUM® (loperamide hydrochloride) overdosage.
In clinical trials an adult who took three 20mg doses within a 24 hour period was nauseated after the second dose and vomited after the third dose. In studies designed to examine the potential for side effects, intentional ingestion of up to 60 mg of loperamide hydrochloride in a single dose to healthy subjects resulted in no significant adverse effects.
IMODIUM (loperamide hcl) is contraindicated in patients with a known hypersensitivity to loperamide hydrochloride or to any of the excipients.
IMODIUM (loperamide hcl) is not recommended in infants below 24 months of age.
- in patients with acute ulcerative colitis,
- in patients with pseudomembranous colitis associated with the use of broad- spectrum antibiotics.
Last reviewed on RxList: 3/18/2008
This monograph has been modified to include the generic and brand name in many instances.
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