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Impotence (ED) (cont.)

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How effective is testosterone in treating erectile dysfunction?

In patients with hypogonadism, testosterone treatment can improve libido and erectile dysfunction, but the response of erectile dysfunction in men with hypogonadism to testosterone is not complete; many men still may need additional oral medications such as sildenafil, vardenafil, or tadalafil.

In men 40 years of age or older, a breast examination, digital examination of the prostate, and a PSA level (prostate specific antigen) blood test should be done to exclude breast and prostate cancer before starting testosterone treatment since testosterone can aggravate breast and prostate cancers. Patients who have breast and prostate cancers or are suspected of having them should not use testosterone.

Blood testosterone levels can be measured to detect deficiency. Although, there is no clear cut testosterone level to define hypogonadism, levels lower than 250 nanograms per deciliter are considered low, and levels of greater than 350 nanograms per deciliter are considered normal. Testosterone levels in between these numbers may be labeled indeterminate.

Certain medications can alter the gonadal function, including thiazide diuretics, some seizure medications, long-acting oral opiate pain medications, antipsychotic medications, and oral steroids.

Can low testosterone level be replaced?

Because of potential adverse effects and complex metabolism, the use of testosterone replacement therapy (TRT) is limited to men with symptoms of erectile dysfunction and a testosterone level of less than 200 nanogram per deciliter. Preparations available in the U.S. are topical, injectable, and transbuccal (placing inside mouth between the cheek and upper gum) testosterone. Oral preparations are not available in the U.S.

Common side effects of testosterone replacement therapy include local irritations, prostate enlargement, breast tissue enlargement, aggravation of breast and prostate cancers, depression, elevation of red blood cell count (polycythemia), or worsening of congestive heart failure.


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Source: MedicineNet.com
http://www.medicinenet.com/impotence_ed/article.htm


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