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Imuran

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Arthritis is a joint disorder featuring inflammation. A joint is an area of the body where two different bones meet. A joint functions to move the body parts connected by its bones. Arthritis literally means inflammation of one or more joints.

Arthritis is frequently accompanied by joint pain. Joint pain is referred to as arthralgia.

There are many types of arthritis (over 100 identified, and the number is growing). The types range from those related to wear and tear of cartilage (such as osteoarthritis) to those associated with inflammation resulting from an overactive immune system (such as rheumatoid arthritis). Together, the many types of arthritis make up the most common chronic illness in the United States.

The causes of arthritis depend on the form of arthritis. Causes include injury (leading to osteoarthritis), metabolic abnormalities (such as gout and pseudogout), hereditary facto...

Imuran

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Imuran Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Imuran (azathioprine) is used to prevent the body from rejecting a transplanted kidney. It is also used to treat symptoms of rheumatoid arthritis. It is an immunosuppressive antimetabolite. This medication is available in generic form. Common side effects include stomach/intestinal symptoms such as nausea, vomiting, diarrhea, or loss of appetite.

The dose of Imuran to prevent transplant rejection and minimize toxicity varies. The initial dose is usually 3 to 5 mg/kg daily, beginning at the time of transplant. It is usually given as a single daily dose on the day of, and in some cases 1 to 3 days before, transplantation. Maintenance levels of 1 to 3 mg/kg daily are usually possible. For rheumatoid arthritis, the initial dose is approx. 1.0 mg/kg (50 to 100 mg) given as a single dose or twice-daily. Maximum dose is 2.5 mg/kg per day. Imuran may interact with allopurinol, mercaptopurine, methotrexate, blood thinners, cyclosporine, olsalazine, sulfasalazine, sulfamethoxasole, trimethoprim, or ACE inhibitors. Tell your doctor all medications you use. Imuran is not recommended for use during pregnancy. It may harm a fetus. Men and women should use two forms of birth control (e.g., condoms, birth control pill) while taking this medication. This medication can decrease the effectiveness of intrauterine devices (IUDs). Talk to your doctor about birth control. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended.

Our Imuran (azathioprine) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Imuran Prescribing Information: Indications & Dosage

® IMURAN (azathioprine) Structural Formula Illustration

IMURAN is indicated as an adjunct for the prevention of rejection in renal homotransplantation. It is also indicated for the management of active rheumatoid arthritis to reduce signs and symptoms.

Renal Homotransplantation

IMURAN is indicated as an adjunct for the prevention of rejection in renal homotransplantation. Experience with over 16,000 transplants shows a 5-year patient survival of 35% to 55%, but this is dependent on donor, match for HLA antigens, anti-donor or anti-B-cell alloantigen antibody, and other variables. The effect of IMURAN on these...

Read the complete drug monograph for Imuran »

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Imuran Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pale skin, easy bruising or bleeding, unusual weakness;
  • fever, chills, sore throat, body aches, weakness, muscle pain, flu symptoms;
  • severe nausea, vomiting, or diarrhea;
  • severe pain in your upper stomach spreading to your back, fast heart rate;
  • pain or burning with urination;
  • stomac...

Read the complete patient information for Imuran »

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Imuran Consumer Information: Uses

Azathioprine is used with other medications to prevent rejection of a kidney transplant. It works by weakening your body's defense system (immune system) to help your body accept the new kidney as if it were your own. This medication belongs to a class of drugs known as immunosuppressants.

Azathioprine is also used to treat patients with severe rheumatoid arthritis who have not responded to other medications (e.g., nonsteroidal anti-inflammatory drugs/NSAIDs such as ibuprofen). Rheumatoid arthritis is thought to be caused by the immune system attacking the joints. Early treatment of rheumat...

Read the complete consumer information for Imuran »

What is Imuran Consumer Information?

Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More

Imuran - User Reviews

Imuran User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Imuran sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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