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Increlex

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Increlex

INCRELEX®
(mecasermin [rDNA origin]) Injection




DRUG DESCRIPTION

INCRELEX® (mecasermin [rDNA origin] injection) contains human insulin-like growth factor-1 (rhIGF-1) produced by recombinant DNA technology. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.

INCRELEX® is a sterile, aqueous, clear and colorless solution intended for subcutaneous injection. Each multi-dose vial of INCRELEX® contains 10 mg per mL mecasermin, 9 mg per mL benzyl alcohol, 5.84 mg per mL sodium chloride, 2 mg per mL polysorbate 20, and 0.05M acetate at a pH of approximately 5.4.

What are the possible side effects of mecasermin (Increlex)?

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your child's face, lips, tongue, or throat.

Call your doctor at once if your child has a serious side effect such as:

  • blurred vision, severe headache or pain behind the eyes, sometimes with vomiting;
  • pain in the hip or knee, walking with a limp;
  • seizure (convulsions); or
  • swollen tonsils -- snoring, breathing problems during sleep, pain or fullness in your ear, hearing problems.

Less serious side effects...

Read All Potential Side Effects and See Pictures of Increlex »

Last reviewed on RxList: 6/16/2014
This monograph has been modified to include the generic and brand name in many instances.

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