Inderal LA (Propranolol) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 3, 2012

Inderal LA

Calcium Channel Blockers (CCBs) »

What are calcium channel blockers (CCBs) and how do they work?

Calcium channel blockers are drugs that block the entry of calcium into the muscle cells of the heart and arteries.

The entry of calcium is critical for the conduction of the electrical signal that passes from muscle cell to muscle cell of the heart, and signals the cells to contract.
It also is necessary in order for the muscle cells to contract and thereby pump blood.
In the arteries, the entry of calcium into muscle cells causes contraction of the cells and thereby dilates (widens) the arteries.
Thus, by blocking the entry of calcium, calcium channel blockers reduce electrical conduction within the heart, decrease the force of contraction (work) of the muscle cells, and dilate arteries.
Dilation of the arteries reduces blood pressure and thereby the effort the heart must exert to pump blood.
Combined with decr...

Read the Calcium Channel Blockers (CCBs) article »

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Inderal® LA
(propranolol hydrochloride) Long-Acting Capsules

DRUG DESCRIPTION

Inderal® (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent chemically described as 2-Propanol, l-[(l-methylethyl)amino]-3-(l-naphthalenyloxy)-, hydrochloride,(±)-. Its molecular and structural formulae are:

Inderal® LA
(propranolol hydrochloride) Long-Acting Capsules Structural Formula Illustration

C₁₆H₂₁NO₂ · HCl

Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

Inderal LA is formulated to provide a sustained release of propranolol hydrochloride. Inderal LA (propranolol) is available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration.

The inactive ingredients contained in Inderal LA (propranolol) capsules are: cellulose, ethylcellulose, gelatin capsules, hypromellose, and titanium dioxide. In addition, Inderal LA (propranolol) 60 mg, 80 mg, and 120 mg capsules contain D&C Red No. 28 and FD&C Blue No. 1; Inderal LA (propranolol) 160 mg capsules contain FD&CBlueNo. 1.

These capsules comply with USP Dissolution Test 1.

What are the possible side effects of propranolol (Inderal, Inderal LA, InnoPran XL)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

fast, slow, or uneven heartbeats;
feeling light-headed, fainting;
feeling short of breath, even with mild exertion;
swelling of your ankles or feet;
fever, sore throat, and headache with a severe blistering, peeling, and red...

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What are the precautions when taking propranolol (Inderal LA)?

Before taking propranolol, tell your doctor or pharmacist if you are allergic to it; or if you have had a serious reaction to other beta blockers (e.g., metoprolol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (sinus bradycardia, second- or third-degree atrioventricular block), severe heart failure, asthma.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other breathing problems (e.g., bronchitis,...

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Last reviewed on RxList: 10/12/2010
This monograph has been modified to include the generic and brand name in many instances.