Inderide (Propranolol Hydrochloride and Hydrochlorothiazide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Inderide

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High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

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Inderide

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INDERIDE® (propranolol hydrochloride and hydrochlorothiazide)
(propranolol hydrochloride [Inderal®] and Hydrochlorothiazide)

DRUG DESCRIPTION

Inderide (propranolol hydrochloride and hydrochlorothiazide) Tablets for oral administration combine two antihypertensive agents: Inderal (propranolol hydrochloride), a beta-adrenergic blocking agent, and hydrochlorothiazide, a thiazide diuretic-antihypertensive. Inderide (propranolol hydrochloride and hydrochlorothiazide) 40/25 Tablets contain 40 mg propranolol hydrochloride and 25 mg hydrochlorothiazide; Inderide (propranolol hydrochloride and hydrochlorothiazide) 80/25 Tablets contain 80 mg propranolol hydrochloride and 25 mg hydrochlorothiazide.

Inderal (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent chemically described as 2-Propanol, l-[(l-methylethyl)amino]-3-(l-naphthalenyloxy)-, hydrochloride,(±)-. Its structural formula is:

Propranolol hydrochloride Structural Formula Illustration

Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

Hydrochlorothiazide is a white, or practically white, practically odorless, crystalline powder. It is slightly soluble in water; freely soluble in sodium hydroxide solution; sparingly soluble in methanol; insoluble in ether, chloroform, benzene, and dilute mineral acids. Its chemical name is: 6-Chloro-3,4-dihydro-2H-l,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its structural formula is:

Hydrochlorothiazide Structural Formula Illustration

The inactive ingredients contained in Inderide (propranolol hydrochloride and hydrochlorothiazide) Tablets are lactose, magnesium stearate, microcrystalline cellulose, stearic acid, and yellow ferric oxide.

What are the possible side effects of hydrochlorothiazide and propranolol (Inderide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
easy bruising or bleeding;
numbness or tingly feeling in your hands or feet;
feeling...

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What are the precautions when taking propranolol hydrochloride and hydrochlorothiazide (Inderide)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to propranolol or hydrochlorothiazide; or to other thiazides (e.g., chlorothiazide); or if you have had a serious reaction to other beta blockers (e.g., metoprolol, atenolol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (sinus bradycardia, second- or third-degree atrioventricular block), severe heart failure, asthma, an inability to make urine (anuria).

Before using this...

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Last reviewed on RxList: 5/13/2011
This monograph has been modified to include the generic and brand name in many instances.