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Inderide (propranolol hydrochloride and hydrochlorothiazide) is indicated in the management of hypertension.
This fixed combination is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management.
DOSAGE AND ADMINISTRATION
The dosage must be determined by individual titration.
Hydrochlorothiazide can be given at doses of 12.5 to 50 mg per day when used alone. The initial dose of propranolol is 80 mg daily, and it may be increased gradually until optimal blood pressure control is achieved. The usual effective dose when used alone is 160 to 480 mg per day.
One Inderide (propranolol hydrochloride and hydrochlorothiazide) Tablet twice daily can be used to administer up to 160 mg of propranolol and 50 mg of hydrochlorothiazide. For doses of propranolol greater than 160 mg the combination products are not appropriate, because their use would lead to an excessive dose of the thiazide component.
When necessary, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure.
Inderide (propranolol hydrochloride and hydrochlorothiazide) 40/25
Each hexagonal-shaped, off-white, scored tablet, embossed with an "I" and imprinted with "INDERIDE (propranolol hydrochloride and hydrochlorothiazide) 40/25," contains 40 mg propranolol hydrochloride (InderalR) and 25 mg hydrochlorothiazide, in bottles of 100 (NDC 24090-484-88).
Inderide (propranolol hydrochloride and hydrochlorothiazide) 80/25 Each hexagonal-shaped, off-white, scored tablet, embossed with an "I" and imprinted with "INDERIDE (propranolol hydrochloride and hydrochlorothiazide) 80/25," contains 80 mg propranolol hydrochloride (InderalR) and 25 mg hydrochlorothiazide, in bottles of 100 (NDC 24090-488-88).
Store at 20° to 25°C (68° to 77°F); excursions permitted to 15°-30°C (59°-86°C). [See USP Controlled Room Temperature]
Protect from moisture, freezing, and excessive heat.
Dispense in a well-closed container as defined in the USP.
The appearance of these tablets is a registered trademark of Wyeth Pharmaceuticals.
This product's label may have been updated. For current package insert and further product information, call our medical communications department toll-free at 888-38-1733. Manufactured for: Akrimax Pharmaceuticals, LLC Cranford, NJ 07016. By: Wyeth Pharmaceuticals Inc. Philadelphia, PA 19101. Revv date 01/2011
Last reviewed on RxList: 5/13/2011
This monograph has been modified to include the generic and brand name in many instances.
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