In this Article
- What other names is Indole-3-carbinol known by?
- What is Indole-3-carbinol?
- How does Indole-3-carbinol work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Indole-3-carbinol.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.
Some medications are changed and broken down by the liver. Indole-3-carbinol might increase how quickly the liver breaks down some medications. Taking indole-3-carbinol along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking indole-3-carbinol, talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
- For treating abnormal cells on the surface of the cervix (cervical dysplasia): 200-400 mg per day has been used. However, 200 mg seems to be as effective as the higher dose.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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