Infanrix (Diphtheria and Tetanus Toxoids and Acellular Pertussis) Drug Information: Overdosage and Contraindications

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May 27, 2012

Infanrix

Whooping Cough (Pertussis) »

Whooping cough (pertussis) facts

Whooping cough (pertussis) is an acute, highly contagious respiratory infection that is caused by the bacterium Bordetella pertussis.
Whooping cough commonly affects infants and young children but can be prevented by immunization with pertussis vaccine.
Adults may develop whooping cough as their immunity from childhood vaccines wears off over time.
Clinical symptoms occur in three stages; the characteristic bursts of coughing are observed in the second, or paroxysmal, stage.
Antibiotics can help reduce the severity of the disease when administered early in the course of the disease.
Secondary bacterial pneumonia is the most common complication of whooping cough.

What is whooping cough? What is the history of whooping cough?

Whooping cough is a bacterial upper respiratory infection that leads to episodes of violent coughing. The d...

Read the Whooping Cough (Pertussis) article »

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OVERDOSE

No information provided.

CONTRAINDICATIONS

Hypersensitivity to any component of the vaccine is a contraindication (see DESCRIPTION).

It is a contraindication to use this vaccine after a serious allergic reaction (e.g., anaphylaxis) temporally associated with a previous dose of this vaccine or with any components of this vaccine. Because of the uncertainty as to which component of the vaccine might be responsible, no further vaccination with any of these components should be given. Alternatively, such individuals may be referred to an allergist for evaluation if immunizations are to be considered.²

In addition, the following events are contraindications to administration of any pertussis-containing vaccine, including INFANRIX (diphtheria and tetanus toxoids and acellular pertussis) :⁵

Encephalopathy (e.g., coma, decreased level of consciousness, prolonged seizures) within 7 days of administration of a previous dose of a pertussis-containing vaccine that is not attributable to another identifiable cause;
Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy, or progressive encephalopathy. Pertussis vaccine should not be administered to individuals with these conditions until a treatment regimen has been established and the condition has stabilized.

In instances where the pertussis vaccine component is contraindicated, Diphtheria and Tetanus Toxoids Adsorbed (DT) For Pediatric Use should be administered.²

REFERENCES

2. Centers for Disease Control. Diphtheria, tetanus, and pertussis: Recommendations for vaccine use and other preventive measures — Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 1991;40(RR-10):1-28.

5. Centers for Disease Control and Prevention. General recommendations on immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP). MMWR 2002;51(RR-2):1-35.

Last reviewed on RxList: 3/6/2009
This monograph has been modified to include the generic and brand name in many instances.