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INFeD

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Infed




Indications
Dosage
How Supplied

INDICATIONS

Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible.

DOSAGE AND ADMINISTRATION

Oral iron should be discontinued prior to administration of INFeD.

Dosage

Iron Deficiency Anemia

Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state.

After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count.

Although serum ferritin is usually a good guide to body iron stores, the correlation of body iron stores and serum ferritin may not be valid in patients on chronic renal dialysis who are also receiving iron dextran complex.

Although there are significant variations in body build and weight distribution among males and females, the accompanying table and formula represent a convenient means for estimating the total iron required. This total iron requirement reflects the amount of iron needed to restore hemoglobin concentration to normal or near normal levels plus an additional allowance to provide adequate replenishment of iron stores in most individuals with moderately or severely reduced levels of hemoglobin. It should be remembered that iron deficiency anemia will not appear until essentially all iron stores have been depleted. Therapy, thus, should aim at not only replenishment of hemoglobin iron but iron stores as well.

Factors contributing to the formula are shown below.

mg blood iron = = mL blood x g hemoglobin x mg iron
lb body weight lb body weight mL blood g hemoglobin

  1. Blood volume . . . . . . . . . . . . . . . .65 mL/kg of body weight
  2. Normal hemoglobin (males and females)
    over 15 kg (33 lbs) . . . . . . . . . . . .14.8 g/dl
    15 kg (33 lbs) or less . . . . . . . . . .12.0 g/dl
  3. Iron content of hemoglobin . . . . . 0.34%
  4. Hemoglobin deficit
  5. Weight

Based on the above factors, individuals with normal hemoglobin levels will have approximately 33 mg of blood iron per kilogram of body weight (15 mg/lb).

Note: The table and accompanying formula are applicable for dosage determinations only in patients with iron deficiency anemia; they are not to be used for dosage determinations in patients requiring iron replacement for blood loss.

TOTAL INFeD REQUIREMENT FOR HEMOGLOBIN RESTORATION AND IRON STORES REPLACEMENT*

PATIENT LEAN BODY WEIGHT Milliliter Requirement of INFeD Based On Observed Hemoglobin of
kg lb 3(g/dl) 4(g/dl) 5(g/dl) 6(g/dl) 7(g/dl) 8(g/dl) 9(g/dl) 10(g/dl)
5
11 3 3 3 3 2 2 2 2
10
22 7 6 6 5 5 4 4 3
15
33 10 9 9 8 7 7 6 5
20
44 16 15 14 13 12 11 10 9
25
55 20 18 17 16 15 14 13 12
30
66 23 22 21 19 18 17 15 14
35
77 27 26 24 23 21 20 18 17
40
88 31 29 28 26 24 22 21 19
45
99 35 33 31 29 27 25 23 21
50
110 39 37 35 32 30 28 26 24
55
121 43 41 38 36 33 31 28 26
60
132 47 44 42 39 36 34 31 28
65
143 51 48 45 42 39 36 34 31
70
154 55 52 49 45 42 39 36 33
75
165 59 55 52 49 45 42 39 35
80
176 63 59 55 52 48 45 41 38
85
187 66 63 59 55 51 48 44 40
90
198 70 66 62 58 54 50 46 42
95
209 74 70 66 62 57 53 49 45
100
220 78 74 69 65 60 56 52 47
105
231 82 77 73 68 63 59 54 50
110
242 86 81 76 71 67 62 57 52
115
253 90 85 80 75 70 64 59 54
120
264 94 88 83 78 73 67 62 57
*Table values were calculated based on a normal adult hemoglobin of 14.8 g/dl for weights greater than 15 kg (33 lbs) and a hemoglobin of 12.0 g/dl for weights less than or equal to 15 kg (33 lbs).

The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows:

Adults and Children over 15 kg (33 lbs): See Dosage Table. Alternatively the total dose may be calculated:

Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW)
Based on: Desired Hb = the target Hb in g/dl.
Observed Hb = the patient's current hemoglobin in g/dl.
LBW = Lean body weight in kg. A patient's lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage.
For males: LBW = 50 kg + 2.3 kg for each inch of patient's height over 5 feet
For females: LBW = 45.5 kg + 2.3 kg for each inch of patient's height over 5 feet

To calculate a patient's weight in kg when lbs are known:

patient's weight in pounds /2.2 = weight in kilograms

Children 5 - 15 kg (11 - 33 lbs): See Dosage Table.

INFeD should not normally be given in the first four months of life. (See PRECAUTIONS: Pediatric Use.)

Alternatively the total dose may be calculated:

Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x W + (0.26 x W)
Based on: Desired Hb = the target Hb in g/dl. (Normal Hb for Children 15 kg or less is 12 g/dl)
W = Weight in kg.

To calculate a patient's weight in kg when lbs are known:

patient's weight in pounds /2.2 = weight in kilograms

Iron Replacement for Blood Loss

Some individuals sustain blood losses on an intermittent or repetitive basis. Such blood losses may occur periodically in patients with hemorrhagic diatheses (familial telangiectasia; hemophilia; gastrointestinal bleeding) and on a repetitive basis from procedures such as renal hemodialysis.

Iron therapy in these patients should be directed toward replacement of the equivalent amount of iron represented in the blood loss. The table and formula described under I. Iron Deficiency Anemia are not applicable for simple iron replacement values.

Quantitative estimates of the individual's periodic blood loss and hematocrit during the bleeding episode provide a convenient method for the calculation of the required iron dose.

The formula shown below is based on the approximation that 1 mL of normocytic, normochromic red cells contains 1 mg of elemental iron:

Replacement iron (in mg) = Blood loss (in mL) x hematocrit
Example: Blood loss of 500 mL with 20% hematocrit
Replacement Iron = 500 x 0.20 = 100 mg
INFeD dose = 100 mg /50 = 2 mL

Administration

The total amount of INFeD required for the treatment of iron deficiency anemia or iron replacement for blood loss is determined from the table or appropriate formula. (See Dosage).

1. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given.

Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute.

2. Intramuscular Injection - PRIOR TO THE FIRST INTRAMUSCULAR INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAMUSCULAR TEST DOSE OF 0.5 ML. (See BOXED WARNING and PRECAUTIONS.) The test dose should be administered in the buttock using the same technique as described in the last paragraph of this section. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes or sooner, it is recommended that at least an hour or longer elapse before the remainder of the initial therapeutic dose is given.

If no adverse reactions are observed, INFeD can be given according to the following schedule until the calculated total amount required has been reached. Each day's dose should ordinarily not exceed 0.5 mL (25 mg of iron) for infants under 5 kg (11 lbs); 1.0 mL (50 mg of iron) for children under 10 kg (22 lbs); and 2.0 mL (100 mg of iron) for other patients.

INFeD should be injected only into the muscle mass of the upper outer quadrant of the buttock - never into the arm or other exposed areas - and should be injected deeply, with a 2-inch or 3-inch 19 or 20 gauge needle. If the patient is standing, he/she should be bearing his/her weight on the leg opposite the injection site, or if in bed, he/she should be in the lateral position with injection site uppermost. To avoid injection or leakage into the subcutaneous tissue, a Z-track technique (displacement of the skin laterally prior to injection) is recommended.

NOTE: Do not mix INFeD with other medications or add to parenteral nutrition solutions for intravenous infusion.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.

HOW SUPPLIED

INFeD (Iron Dextran Injection USP) containing 50 mg of elemental iron per mL, is available in 2 mL single dose amber vials (for intramuscular or intravenous use) in cartons of 10 (NDC 52544-931-02).

Store at 20 -25°C (68 -77°F) [See USP Controlled Room Temperature].

REFERENCES

1 Hatton RC, Portales IT, Finlay A, Ross EA. Removal of Iron Dextran by Hemodialysis: An In Vitro Study. Am J Kid Dis. 1995; 26(2):327-330.

2 Manuel MA, Stewart WK, St. Clair Neill GD, Hutchinson F. Loss of Iron-Dextran through Cuprophane Membrane of a Disposable Coil Dialyser. Nephron. 1972;9:94-98.

For all medical inquiries contact: ACTAVIS, Medical Communications, Parsippany, NJ 07054 1-800-272-5525

Distributed By: Actavis Pharma, Inc., Parsippany, NJ 07054 USA. Manufactured By: Patheon Italia S.p.A. Ferentino, Italy 03013. Revised: January 2014

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/23/2016

Indications
Dosage
How Supplied

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