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Infergen

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Infergen

OVERDOSE

In INFERGEN trials, the maximum overdose reported was a dose of 150 mcg INFERGEN administered subcutaneously in a subject enrolled in a phase 1 advanced malignancy trial. The subject received 10 times the prescribed dosage for three days and experienced a mild increase in anorexia, chills, fever, and myalgia. Increases in ALT (15 IU/L to 127 IU/L), aspartate transaminase (AST) (15 to 164 IU/L), and lactic dehydrogenase (LDH) (183 IU/L to 281 IU/L) were reported. These laboratory values returned to normal or to the subjects baseline values within 30 days.

CONTRAINDICATIONS

INFERGEN is contraindicated in patients with:

Additionally, ribavirin is contraindicated in:

  • women who are pregnant
  • men whose female partners are pregnant
  • patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia)
  • patients with hypersensitivity to ribavirin or any other component of the product
  • patients with creatinine clearance < 50 mL/min

Last reviewed on RxList: 6/17/2013
This monograph has been modified to include the generic and brand name in many instances.

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