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(axitinib) Film-coated Tablets
INLYTA (axitinib) is a kinase inhibitor. Axitinib has the chemical name N-methyl-2-[3-((E)2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide. The molecular formula is C22H18N4OS and the molecular weight is 386.47 Daltons. The chemical structure is :
Axitinib is a white to light-yellow powder with a pKa of 4.8. The solubility of axitinib in aqueous media over the range pH 1.1 to pH 7.8 is in excess of 0.2 μg/mL. The partition coefficient (n-octanol/water) is 3.5.
INLYTA is supplied as red, film-coated tablets containing either 1 mg or 5 mg of axitinib together with microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, and Opadry® II red 32K15441 as inactive ingredients. The Opadry II red 32K15441 film coating contains lactose monohydrate, HPMC 2910/Hypromellose 15cP, titanium dioxide, triacetin (glycerol triacetate), and red iron oxide.
What are the possible side effects of axitinib (Inlyta)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using axitinib and call your doctor at once if you have a serious side effect such as:
- sudden numbness or weakness, problems with speech or balance;
- pain, swelling, warmth, or redness in one or both legs;
- severe headache, confusion, change in mental status, vision loss, and/or seizure (convulsions);
- severe stomach pain;
- red or pink urine, bloody or tarry stools;
Last reviewed on RxList: 8/15/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Inlyta Information
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