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Brand Names: Innohep

Generic Name: tinzaparin (Pronunciation: tin ZA pa rin)

• What is tinzaparin (Innohep)?
• What are the possible side effects of tinzaparin (Innohep)?
• What is the most important information I should know about tinzaparin (Innohep)?
• What should I discuss with my healthcare provider before using tinzaparin (Innohep)?
• How should I use tinzaparin (Innohep)?
• What happens if I miss a dose (Innohep)?
• What happens if I overdose (Innohep)?
• What should I avoid while using tinzaparin (Innohep)?
• What other drugs will affect tinzaparin (Innohep)?
• Where can I get more information?

What is tinzaparin (Innohep)?

Tinzaparin is a blood thinner (anticoagulant) that prevents blood clots from forming in the body.

Tinzaparin is used together with warfarin (Coumadin) to treat a type of blood clot called deep vein thrombosis, or DVT. This condition sometimes occurs with a blood clot in lungs (pulmonary embolism).

Tinzaparin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of tinzaparin (Innohep)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tinzaparin and call your doctor at once if you have any of these serious side effects:

• unusual bleeding such as nosebleeds, bleeding gums, or any bleeding that will not stop;
• pale skin, weakness, easy bruising, purple or red pinpoint spots under your skin;
• unexpected vaginal bleeding;
• blood in your urine or stools, black or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• numbness or tingly feeling, trouble swallowing;
• loss of movement in any part of your body;
• chest pain, stomach pain, shortness of breath;
• fever;
• feeling like you might pass out; or
• penis erection that is painful or lasts 4 hours or longer;

Less serious side effects may include:

• mild headache, dizziness;
• back pain, mild joint or muscle pain;
• pain, irritation, swelling, or bruising of the skin where the medicine was injected;
• nausea, vomiting, upset stomach, gas;
• pain or burning when you urinate;
• diarrhea, constipation; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tinzaparin (Innohep)?

You should not use this medication if you have low levels of blood platelets caused by using heparin, or if you are allergic to tinzaparin, heparin, sulfites, benzyl alcohol, or pork products.

Tinzaparin may cause severe or life-threatening side effects if you use it while you have any active bleeding or hemorrhage, or if you have: a bleeding disorder, hemorrhagic stroke, bacterial endocarditis, severe high blood pressure, stomach bleeding, liver failure, amyloidosis (a build-up of certain proteins in tissues and organs of the body), recent brain/spine or eye surgery, or if you are 70 years or older and have not recently had your kidney function checked.

Tell your doctor about all other medications you have recently used, especially drugs that can prevent blood from clotting, such as heparin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), ticlopidine (Ticlid), non-steroidal anti-inflammatory drugs (NSAIDs), and others.

Call your doctor at once if you have any signs of bleeding, such as pale skin, weakness, easy bruising, unexpected vaginal bleeding, blood in your urine or stools, coughing up blood, or any bleeding that will not stop.

If you undergo a spinal tap or any type of spinal anesthesia (such as an epidural), tell the doctor ahead of time that you are using tinzaparin. You may need to stop using the medicine for a short time before having such procedures.