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InnoPran XL

Last reviewed on RxList: 1/13/2017
InnoPran XL Side Effects Center

Last reviewed on RxList 2/23/2016

Innopran XL (propranolol hydrochloride) is a beta-blocker used to treat tremors, angina (chest pain), hypertension (high blood pressure), heart rhythm disorders, and other heart or circulatory conditions. Innopran XL is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches. Common side effects of Innopran XL include dizziness, lightheadedness, or tiredness as the body adjusts to the medication. Other side effects of Innopran XL include nausea, vomiting, stomach pain, stomach cramps, diarrhea, constipation, vision changes, trouble sleeping (insomnia), unusual dreams, decreased sex drive, impotence, and difficulty having an orgasm.

The starting dose of Innopran XL is 80 mg but adjustment may be needed to a dose of 120 mg. Take once daily at bedtime, consistently either on an empty stomach or with food. Innopran XL may interact with clonidine, digitalis, dobutamine, haloperidol, isoproterenol, blood thinners, antidepressants, MAO inhibitors, aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), doxazosin, prazosin, terazosin, heart medications, amiodarone, propafenone, quinidine, or ACE inhibitors. Tell your doctor all medications and supplements you use. During pregnancy, Innopran XL should be used only when prescribed. Infants exposed to this medication during pregnancy may have low birth weight, low blood sugar, or slow breathing/heartbeat. Discuss the risks and benefits with your doctor. This drug passes into breast milk. Consult your doctor before breastfeeding.

Our Innopran XL (propranolol hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

InnoPran XL Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heartbeats;
  • feeling light-headed, fainting;
  • feeling short of breath, even with mild exertion;
  • swelling of your ankles or feet;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • cold feeling in your hands and feet;
  • depression, confusion, hallucinations; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • nausea, vomiting, diarrhea, constipation, stomach cramps;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • sleep problems (insomnia); or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for InnoPran XL (Propranolol Hydrochloride)

InnoPran XL Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adverse reactions occurring at a rate of ≥ 3%, excluding those reported more commonly in placebo, encountered in the INNOPRAN XL placebo-controlled hypertension trials and plausibly related to treatment are shown in Table 1.

Table 1: Treatment Emergent Adverse Reactions Reported In ≥ 3% of Subjects

Body System INNOPRAN XL
Placebo
(N=88)
80 mg
(N=89)
120 mg
(N=85)
Fatigue 3 (3%) 4 (5%) 6 (7%)
Dizziness (except vertigo) 2 (2%) 6 (7%) 3 (4%)
Constipation 0 3 (3%) 1 (1%)

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following reactions have been identified during post-marketing use of INNOPRAN XL. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The following adverse reactions were observed and have been reported with use of formulations of sustained-or immediate-release propranolol.

Allergic: Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions; pharyngitis and agranulocytosis; erythematous rash, fever combined with aching and sore throat, laryngospasm, and respiratory distress.

Autoimmune: Systemic lupus erythematosus (SLE).

Cardiovascular: exacerbation of peripheral arterial disease, arterial insufficiency, usually of the Raynaud type.

Central Nervous System: Light-headedness, mental depression, insomnia, lassitude, weakness, fatigue visual disturbances, hallucinations, vivid dreams, short-term memory loss, emotional lability, slightly clouded sensorium, paresthesia of hands

Gastrointestinal: Nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, mesenteric arterial thrombosis, ischemic colitis.

Genitourinary: Male impotence; Peyronie's disease.

Hematologic: Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.

Musculoskeletal: Myopathy, myotonia

Skin and mucous membranes: Stevens-Johnson syndrome, toxic epidermal necrolysis, dry eyes, exfoliative dermatitis, erythema multiforme, urticaria, alopecia, SLE-like reactions, and psoriasisiform rashes.

Read the entire FDA prescribing information for InnoPran XL (Propranolol Hydrochloride)

Related Resources for InnoPran XL

Read the InnoPran XL User Reviews »

© InnoPran XL Patient Information is supplied by Cerner Multum, Inc. and InnoPran XL Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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