"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...
Patients receiving INSPRA should be informed:
- Not to use strong CYP3A4 inhibitors, such as ketoconazole, clarithromycin, nefazodone, ritonavir, and nelfinavir.
- Not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.
- To call their physician if they experience dizziness, diarrhea, vomiting, rapid or irregular heartbeat, lower extremity edema, or difficulty breathing.
- That periodic monitoring of blood pressure and serum potassium is important [see CONTRAINDICATIONS; WARNINGS AND PRECAUTIONS; and DRUG INTERACTIONS].
Last reviewed on RxList: 6/3/2013
This monograph has been modified to include the generic and brand name in many instances.
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