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Inspra

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Inspra

Overdosage
Contraindications

OVERDOSE

No cases of human overdosage with eplerenone have been reported. Lethality was not observed in mice, rats, or dogs after single oral doses that provided Cmax exposures at least 25 times higher than in humans receiving eplerenone 100 mg/day. Dogs showed emesis, salivation, and tremors at a Cmax 41 times the human therapeutic Cmax, progressing to sedation and convulsions at higher exposures.

The most likely manifestation of human overdosage would be anticipated to be hypotension or hyperkalemia. Eplerenone cannot be removed by hemodialysis. Eplerenone has been shown to bind extensively to charcoal. If symptomatic hypotension should occur, supportive treatment should be instituted. If hyperkalemia develops, standard treatment should be initiated.

CONTRAINDICATIONS

For All Patients

INSPRA is contraindicated in all patients with:

  • serum potassium > 5.5 mEq/L at initiation,
  • creatinine clearance ≤ 30 mL/min, or
  • concomitant administration of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir) [see DRUG INTERACTIONS, CLINICAL PHARMACOLOGY].
For Patients Treated for Hypertension

INSPRA is contraindicated for the treatment of hypertension in patients with:

Last reviewed on RxList: 6/3/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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Inspra - User Reviews

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Hypertension

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