Interstitial Lung Disease
(Interstitial Pneumonia, Interstitial Pneumonitis)
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
- What is interstitial lung disease?
- What causes interstitial lung disease?
- What are the symptoms of interstitial lung disease?
- How is interstitial lung disease diagnosed?
- How is interstitial lung disease treated?
- Patient Comments: Interstitial Lung Disease - Describe Your Experience
- Patient Comments: Interstitial Lung Disease - Causes
- Patient Comments: Interstitial Lung Disease - Symptoms
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What is interstitial lung disease?
Interstitial lung disease is a term used to refer to a particular type of inflammation of the interstitium of the lungs. The interstitium is the tissue that surrounds and separates the tiny air sacs (alveolae) in the lungs. Interstitial lung disease involves an inflammation of this supportive tissue between the air sacs rather than inflammation in the air sacs themselves. Interstitial inflammation is typically a diffuse process that occurs all over the lungs and is not confined to one location.
Sometimes the term "interstitial pneumonia" is used for certain forms of interstitial lung disease. Technically, however, the term "pneumonia" refers to inflammation of the lung tissue that is usually associated with infection. Because interstitial lung disease has a number of causes (most of which are not related to infection), the term "interstitial pneumonitis" is occasionally used to refer to the inflammation that occurs in the absence of true infection.
What causes interstitial lung disease?
Interstitial lung disease is felt to be caused by a misdirected immune or healing reaction to a number of factors, including:
- infections of the lungs;
- toxins in the environment (such as
asbestos,
silica dust);
- certain medications (particularly some drugs used as
chemotherapy for
cancers);
- radiation therapy to the chest;
and
- chronic autoimmune diseases: connective tissue diseases such as lupus, scleroderma, and rheumatoid arthritis
Sometimes, the process of inflammation and scarring of the interstitial tissues of the lungs develops in the absence of a known cause. When no cause can be identified, this is referred to as idiopathic (unknown cause) interstitial lung disease or idiopathic pulmonary fibrosis. Depending upon the location, severity, and pattern of lung involvement, the idiopathic interstitial lung diseases have been further subdivided into categories. Examples of different types of idiopathic interstitial lung disease include:
- usual interstitial
pneumonitis (UIP),
- bronchiolitis
obliterans with organizing pneumonia (BOOP),
- lymphocytic interstitial pneumonitis (LIP), and
- desquamative interstitial pneumonitis (DIP).
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