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Intralipid 20 Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Intralipid 20% (20% I.V. Fat Emulsion) is used to provide calories to patients who are getting their nutrition through an injection into the vein. It is also used to provide essential fatty acids to people who do not have enough of it, and it helps to prevent or reverse the signs of fatty acid deficiency (e.g., scaly skin, poor growth, poor wound healing). It is made of 20% soybean oil. This medication is available in generic form. Common side effects include headache, dizziness, flushing, drowsiness, nausea, vomiting, or sweating.
The initial rate of infusion of Intralipid 20% in adults should be 0.5 ml/minute for the first 15 to 30 minutes of infusion. If no untoward reactions occur, the infusion rate can be increased to 1 ml/minute. If there are no adverse reactions, the dose can be increased the following day. The daily dosage should not exceed 2.5 g of fat/kg of body weight (12.5 ml of Intralipid 20% per kg). Intralipid 20% may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Intralipid 20% should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Intralipid 20% (20% I.V. Fat Emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Intralipid 20 Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of infection (e.g., fever, persistent sore throat), pain/swelling/redness at injection site, pain/swelling/redness of arms/legs, bluish skin, sudden weight gain, shortness of breath, back/chest pain.
Tell your doctor immediately if any of these rare but very serious side effects occur: mental/mood changes, bone pain, muscle weakness, yellowing skin/eyes, dark urine, easy bruising/bleeding, severe stomach/abdominal pain, trouble breathing.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Intralipid 20 (20% I.V. Fat Emulsion)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Intralipid 20 FDA Prescribing Information: Side Effects
THE ADVERSE REACTIONS OBSERVED CAN BE SEPARATED INTO TWO CLASSES:
- THOSE MORE FREQUENTLY ENCOUNTERED ARE DUE: EITHER TO CONTAMINATION OF THE INTRAVENOUS CATHETER AND RESULT IN SEPSIS, OR TO VEIN IRRITATION BY CONCURRENTLY INFUSED HYPERTONIC SOLUTIONS AND MAY RESULT IN THROMBOPHLEBITIS. THESE ADVERSE REACTIONS ARE INSEPARABLE FROM THE HYPERALIMENTATION PROCEDURE WITH OR WITHOUT INTRALIPID® 20% (A 20% I.V. FAT EMULSION).
- LESS FREQUENT REACTIONS MORE DIRECTLY RELATED TO INTRALIPID® 20% (20% i.v. fat emulsion) ARE: A) IMMEDIATE OR EARLY ADVERSE REACTIONS, EACH OF WHICH HAS BEEN REPORTED TO OCCUR IN CLINICAL TRIALS, IN AN INCIDENCE OF LESS THAN 1%; DYSPNEA, CYANOSIS, ALLERGIC REACTIONS, HYPERLIPEMIA, HYPERCOAGULABILITY, NAUSEA, VOMITING, HEADACHE, FLUSHING, INCREASE IN TEMPERATURE, SWEATING, SLEEPINESS, PAIN IN THE CHEST AND BACK, SLIGHT PRESSURE OVER THE EYES, DIZZINESS, AND IRRITATION AT THE SITE OF INFUSION, AND, RARELY, THROMBOCYTOPENIA IN NEONATES; B) DELAYED ADVERSE REACTIONS SUCH AS HEPATOMEGALY, JAUNDICE DUE TO CENTRAL LOBULAR CHOLESTASIS, SPLENOMEGALY, THROMBOCYTOPENIA, LEUKOPENIA, TRANSIENT INCREASES IN LIVER FUNCTION TESTS, AND OVERLOADING SYNDROME (FOCAL SEIZURES, FEVER, LEUKOCYTOSIS, HEPATOMEGALY. SPLENOMEGALY AND SHOCK).
THE DEPOSITION OF A BROWN PIGMENTATION IN THE RETICULOEN-DOTHELIAL SYSTEM, THE SO CALLED "INTRAVENOUS FAT PIGMENT," HAS BEEN REPORTED IN PATIENTS INFUSED WITH INTRALIPID® 20% (20% i.v. fat emulsion) . THE CAUSES AND SIGNIFICANCE OF THIS PHENOMENON ARE UNKNOWN.
Read the entire FDA prescribing information for Intralipid 20 (20% I.V. Fat Emulsion)
Additional Intralipid 20% Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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