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(guanfacine) Extended-release Tablets


INTUNIV® is a once-daily, extended-release formulation of guanfacine hydrochloride (HCl) in a matrix tablet formulation for oral administration only. The chemical designation is N-amidino-2-(2,6- dichlorophenyl) acetamide monohydrochloride. The molecular formula is C9H9Cl2N3O•HCl corresponding to a molecular weight of 282.55. The chemical structure is:

INTUNIV (guanfacine) Structural Formula Illustration

Guanfacine HCl is a white to off-white crystalline powder, sparingly soluble in water (approximately 1 mg/mL) and alcohol and slightly soluble in acetone. The only organic solvent in which it has relatively high solubility is methanol ( > 30 mg/mL). Each tablet contains guanfacine HCl equivalent to 1 mg, 2 mg, 3 mg, or 4 mg of guanfacine base. The tablets also contain hypromellose, methacrylic acid copolymer, lactose, povidone, crospovidone, microcrystalline cellulose, fumaric acid, and glyceryl behenate. In addition, the 3-mg and 4-mg tablets also contain green pigment blend PB-1763.

What are the possible side effects of guanfacine (Intuniv, Tenex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast or slow heart rate;
  • pounding heartbeats, chest tightness;
  • numbness or tingling; or
  • feeling like you might pass out.

Less serious side effects may include:

  • drowsiness, dizziness, tired feeling;
  • dry mouth;
  • constipation;
  • stomach pain;
  • weight...

Read All Potential Side Effects and See Pictures of Intuniv »

What are the precautions when taking guanfacine (Intuniv)?

Before taking guanfacine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, fainting, blood pressure problems (both low or high), heart disease (such as slow heart rate), personal/family history of mental/mood disorders (such as bipolar disorder, depression, suicidal thoughts).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic...

Read All Potential Precautions of Intuniv »

Last reviewed on RxList: 7/18/2016
This monograph has been modified to include the generic and brand name in many instances.

Intuniv - User Reviews

Intuniv User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Intuniv sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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