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(ertapenem) for Injection
INVANZ (Ertapenem for Injection) is a sterile, synthetic, parenteral, 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.
Chemically, INVANZ is described as [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[[(3carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt. Its molecular weight is 497.50. The empirical formula is C22H24N3O7SNa, and its structural formula is:
Ertapenem sodium is a white to off-white hygroscopic, weakly crystalline powder. It is soluble in water and 0.9% sodium chloride solution, practically insoluble in ethanol, and insoluble in isopropyl acetate and tetrahydrofuran.
INVANZ is supplied as sterile lyophilized powder for intravenous infusion after reconstitution with appropriate diluent [see DOSAGE AND ADMINISTRATION] and transfer to 50 mL 0.9% Sodium Chloride Injection or for intramuscular injection following reconstitution with 1% lidocaine hydrochloride. Each vial contains 1.046 grams ertapenem sodium, equivalent to 1 gram ertapenem. The sodium content is approximately 137 mg (approximately 6.0 mEq).
Each vial of INVANZ contains the following inactive ingredients: 175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5.
What are the possible side effects of ertapenem (Invanz, Invanz ADD-Vantage)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
- tremors, twitching, or rigid (very stiff) muscles;
- seizures (black-out or convulsions); or
- diarrhea that is watery or bloody.
Less serious side effects may include:
- mild nausea or diarrhea,...
What are the precautions when taking ertapenem injection (Invanz)?
Before using ertapenem, tell your doctor or pharmacist if you are allergic to it; or to penicillins or cephalosporins; or if you have any other allergies. Before receiving this medication by injection into a muscle, also tell your doctor or pharmacist if you are allergic to any amide-type local anesthetics (e.g., lidocaine). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, stomach/intestinal diseases (e.g., colitis).
Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore,...
Last reviewed on RxList: 8/9/2013
This monograph has been modified to include the generic and brand name in many instances.
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