Inversine (Mecamylamine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Inversine

High Blood Pressure »

High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

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Inversine

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INVERSINE®
(mecamylamine HCl)

DRUG DESCRIPTION

INVERSINE® (Mecamylamine HCl) is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. It is N,2,3,3-tetramethyl-bicyclo (2.2.1] heptan- 2 -amine hydrochloride. Its empirical formula is C₁₁H₂₁N • HCI and its structural formula is:

Inversine (Mecamylamine HCI) Structural Formula Illustration

It is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.

INVERSINE (mecamylamine) is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCI. Inactive ingredients are acacia, calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, starch, and talc.

What are the possible side effects of mecamylamine (Inversine)?

If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
abdominal pain, abdominal distention, or diarrhea.

Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience

nausea, vomiting, or constipation;
dry...

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What are the precautions when taking mecamylamine (Inversine)?

Before taking mecamylamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (glaucoma), certain stomach condition (organic pyloric stenosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as chest pain, heart attack), blood flow problems especially to the brain/heart (such as stroke, TIA), kidney disease, bladder/urination problems (such as bladder...

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Last reviewed on RxList: 12/2/2008
This monograph has been modified to include the generic and brand name in many instances.