Inversine (Mecamylamine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Inversine

High Blood Pressure »

What is high blood pressure?

High blood pressure (HBP) or hypertension means high pressure (tension) in the arteries. Arteries are vessels that carry blood from the pumping heart to all the tissues and organs of the body. High blood pressure does not mean excessive emotional tension, although emotional tension and stress can temporarily increase blood pressure. Normal blood pressure is below 120/80; blood pressure between 120/80 and 139/89 is called "pre-hypertension", and a blood pressure of 140/90 or above is considered high.

The top number, the systolic blood pressure, corresponds to the pressure in the arteries as the heart contracts and pumps blood forward into the arteries. The bottom number, the diastolic pressure, represents the pressure in the arteries as the heart relaxes after the contraction. The diastolic pressure reflects the lowest pressure to which the arteries are exposed.

An elevation of the systolic and/or diastolic blood pressure increas...

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Inversine

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INVERSINE®
(mecamylamine HCl)

DRUG DESCRIPTION

INVERSINE® (Mecamylamine HCl) is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. It is N,2,3,3-tetramethyl-bicyclo (2.2.1] heptan- 2 -amine hydrochloride. Its empirical formula is C₁₁H₂₁N • HCI and its structural formula is:

Inversine (Mecamylamine HCI) Structural Formula Illustration

It is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.

INVERSINE (mecamylamine) is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCI. Inactive ingredients are acacia, calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, starch, and talc.

What are the possible side effects of mecamylamine (Inversine)?

If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
abdominal pain, abdominal distention, or diarrhea.

Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience

nausea, vomiting, or constipation;
dry...

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What are the precautions when taking mecamylamine (Inversine)?

Before taking mecamylamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (glaucoma), certain stomach condition (organic pyloric stenosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as chest pain, heart attack), blood flow problems especially to the brain/heart (such as stroke, TIA), kidney disease, bladder/urination problems (such as bladder...

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Last reviewed on RxList: 12/2/2008
This monograph has been modified to include the generic and brand name in many instances.