"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
The procedure is already available in Europe and "...
INVERSINE® (Mecamylamine HCl) is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. It is N,2,3,3-tetramethyl-bicyclo (2.2.1] heptan- 2 -amine hydrochloride. Its empirical formula is C11H21N • HCI and its structural formula is:
It is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.
INVERSINE (mecamylamine) is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCI. Inactive ingredients are acacia, calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, starch, and talc.
What are the possible side effects of mecamylamine (Inversine)?
If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
- abdominal pain, abdominal distention, or diarrhea.
Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience
- nausea, vomiting, or constipation;
- dry mouth;
- decreased appetite;
- dizziness and...
What are the precautions when taking mecamylamine (Inversine)?
Before taking mecamylamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, narrowing of the opening from stomach into intestines (organic pyloric stenosis), heart problems (such as chest pain, heart attack), blood flow problems especially to the brain (such as stroke), kidney disease, bladder/urination problems (such as bladder neck obstruction, urethral stricture), enlarged prostate (prostatic hypertrophy), salt-restricted diet.
Before having surgery, tell your doctor or dentist...
Last reviewed on RxList: 12/2/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Inversine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.